Glia cells of the monkey retina .2. Muller cells
Glia cells of the monkey retina .2. Muller cells
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DOI：
10.1016/0042-6989(96)00005-3
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发表时间：
1996-08-01
期刊：
影响因子：
1.8
通讯作者：
Dreher, Z
中科院分区：
文献类型：
--
作者：
Distler, C;Dreher, Z
在本文中，第一次定量描述的形态和分布的Muller细胞在猕猴视网膜免疫组织化学和高分辨率共聚焦激光扫描显微镜。通过它们的形态学特征，Muller细胞理想地适应它们在各个视网膜层中的神经元环境，具有密集的水平突起网络，特别是在内部丛状层中，并且与神经元胞体密切接触，特别是在外核层和神经节细胞层中。随着视网膜偏心率的增加，内干细胞的厚度明显增加，从视网膜的总厚度来看，中央部的Muller细胞比周边部的长。在小脑旁区，外丛状层的苗勒细胞的外干被极大地拉长。这些Muller纤维可以达到几百微米的长度，因为它们从中央凹中心向中央凹边界穿过外丛状层，在那里它们进入内核层。Muller细胞密度在远周边的6000个细胞/mm 2和视网膜旁的> 30，000个细胞/mm 2的峰值密度之间变化。猴视网膜中穆勒细胞与血管之间存在密切的空间关系，表明穆勒细胞在血视网膜屏障的形成、营养物质的吸收和代谢物的处理中发挥作用。版权所有（C）1996 Elsevier Science Ltd.
In this paper, for the first time a quantitative description of the morphology and distribution of Muller cells in the macaque monkey retina using immunohistochemistry and high resolution confocal laser scanning microscopy is given. By their morphological features Muller cells are ideally adapted to their neuronal environment in the various retinal layers, with a dense network of horizontal processes, especially in the inner plexiform layer, and close contacts to neuronal somata especially in the outer nuclear layer and ganglion cell layer. Morphology varies with retinal eccentricity, The thickness of the inner trunk increases significantly with increasing retinal eccentricity, According to the overall thickness of the retina, Muller cells in central retina are longer than in peripheral regions. In the parafoveal region, the outer trunks of Muller cells in the outer plexiform layer are immensely elongated. These Muller fibres can reach lengths of several hundred micrometers as they travel through the outer plexiform layer from the foveal centre towards the foveal border where they enter the inner nuclear layer. Muller cell density varies between 6000 cells/mm(2) in far peripheral and peak densities of >30,000 cells/mm(2) in the parafoveal retina. There is a close spatial relationship between Muller cells and blood vessels in the monkey retina, suggesting a role of Muller cells in the formation of the blood-retinal barrier, in the uptake of nutrients and the disposal of metabolites. Copyright (C) 1996 Elsevier Science Ltd.