The alpha-neurotoxin erabutoxin b causes fade at the rat end-plate.
The alpha-neurotoxin erabutoxin b causes fade at the rat end-plate.
复制标题
α-神经毒素艾布毒素 b 会导致大鼠终板褪色。
DOI：
10.1016/0014-2999(90)90127-r
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发表时间：
1990
影响因子：
5
通讯作者：
Chau,WC
中科院分区：
文献类型：
--
作者：
Bradley,RJ;Edge,MT;Chau,WC
d-管库碱和来自蛇毒的α-神经毒素是烟碱乙酰胆碱受体的拮抗剂。d-管库尔碱引起重复神经刺激时神经肌肉传递减弱，这是公认的事实，但矛盾的是，有许多报告表明α-神经毒素不会引起这种减弱。我们发现，高浓度的半筋膜flaticauda半筋膜蛇毒erabutoxin b （100-150 nM）对大鼠隔膜制备没有太大的褪色作用。然而，低浓度的毒素（5 nM）引起严重的褪色，这与d-管curarine的效果相似。这些数据表明，褪色可能是由毒素结合到突触后乙酰胆碱受体的高亲和力位点引起的。
d-Tubocurarine and the α-neurotoxins from snake venom are antagonists at the nicotinic acetylcholine receptor. It is well established that d-tubocurarine causes fade in neuromuscular transmission during repetitive nerve stimulation but paradoxically there are many reports which indicate that the α-neurotoxins do not cause such fade. We found that high concentrations of erabutoxin b (100–150 nM) from the venom ofLaticauda semifasciatadid not cause much fade in the rat diaphragm preparation. However, low concentrations of toxin (5 nM) caused severe fade which was similar to the effects of d-tubocurarine. The data suggest that fade may be caused by toxin binding to a high-affinity site on the postsynaptic acetylcholine receptor.