A novel candidate for wound dressing: Transparent porous maghemite/cellulose nanocomposite membranes with controlled release of doxorubicin from a simple approach.
A novel candidate for wound dressing: Transparent porous maghemite/cellulose nanocomposite membranes with controlled release of doxorubicin from a simple approach.
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DOI：
10.1016/j.msec.2017.05.019
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发表时间：
2017-10
期刊：
影响因子：
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通讯作者：
Hao Zhang;Xiaogang Luo;Hu Tang;Mingming Zheng;Fenghong Huang
中科院分区：
文献类型：
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作者：
Hao Zhang;Xiaogang Luo;Hu Tang;Mingming Zheng;Fenghong Huang
本研究的目的是开发具有高孔隙率、高吸附能力和可控释放阿霉素的透明磁赤铁矿/纤维素纳米复合膜，作为伤口敷料的候选材料。通过在NaOH/尿素水溶液体系中混合均匀分散的柠檬酸盐包裹的磁赤铁矿纳米颗粒和纤维素，采用带铸法制备了膜。通过透光率、扫描电镜（SEM）、傅里叶变换红外光谱（FT-IR）、x射线衍射（XRD）、差示扫描量热（DSC）、拉伸测试和振动样品磁强计（VSM）对制备的膜进行了表征。此外，还对孔隙率、溶胀性、失水率和牛血清白蛋白吸附能力进行了评价。以盐酸阿霉素为模型药物，考察药物的加载与释放。并进行了体外细胞毒性和细胞形态学的研究。该研究证明了磁赤铁矿/纤维素纳米复合膜作为伤口敷料的候选材料，装载和释放生物活性化合物的可行性。
The aim of this study is to develop transparent maghemite/cellulose nanocomposite membranes with high porosity, high adsorption capacity and controlled release of doxorubicin to be used as a candidate for wound dressing. The membranes were fabricated by a tape casting method through blending a homogeneous dispersion of citrate coated maghemite nanoparticles and cellulose in the NaOH/urea aqueous solution system. The prepared membranes were characterized by Light transmittance measurements, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray Diffractometry (XRD), Differential scanning calorimetry (DSC), Tensile tests and Vibrating sample magnetometer (VSM). Furthermore, porosity, swelling behavior, water loss ratio and Bovine serum albumin adsorption capacity were evaluated. Drug loading and release was investigated using doxorubicin hydrochloride as a model drug. In vitro cytotoxicity and cells morphology assays of cells growth and proliferation were also studied. This study served as a demonstration of the feasibility of maghemite/cellulose nanocomposite membranes for loading and release of bioactive compounds as a candidate for wound dressing.