Factor XIII Val34Leu polymorphism and the risk of myocardial infarction under the age of 36 years
Factor XIII Val34Leu polymorphism and the risk of myocardial infarction under the age of 36 years
复制标题
因子XIII Val34Leu多态性与36岁以下心肌梗死风险
DOI：
10.1160/th07-12-0755
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发表时间：
2008
影响因子：
6.7
通讯作者：
D. Kremastinos
中科院分区：
文献类型：
--
作者：
L. Rallidis;M. Politou;C. Komporozos;D. Panagiotakos;Chrisoula I Belessi;A. Travlou;J. Lekakis;D. Kremastinos
关于因子XIII（FXIII）Val 34 Leu多态性在早发性心肌梗死（MI）发病机制中的影响，数据有限且存在争议。我们研究了FXIIIVal 34 Leu多态性是否与早期MI的发生相关。我们招募了159名连续的患者，他们在36岁以下首次急性MI存活（平均年龄=32.1 ± 3.6岁，138名男性）。对照组由121名与病例年龄和性别相匹配、无早发冠心病（CHD）家族史的健康人组成。聚合酶链反应和反向杂交检测FXIII Val 34 Leu基因多态性。患者中Leu 34等位基因携带者的患病率低于对照组（30.2% vs. 47.1%，p=0.006）。校正主要心血管危险因素后，FXIII Val 34 Leu多态性与急性MI风险降低相关（比值比[OR] = 0.51，95%置信区间[CI] 0.27-0.95，p=0.03）。根据血管造影结果（“正常”冠状动脉[n=29]或显著CHD [n=130]）进行的亚组分析显示，在调整主要心血管危险因素后，与对照组相比，只有MI和显著CHD患者的Leu 34等位基因携带者患病率较低（OR = 0.42，95%CI 0.22-0.83，p=0.01）。我们的数据表明，FXIII Val 34 Leu多态性对36岁以下的MI的发展具有保护作用，特别是在显著的CHD的情况下。
Summary There are limited and controversial data regarding the impact of factor XIII (FXIII) Val34Leu polymorphism in the pathogenesis of premature myocardial infarction (MI). We examined whether FXIII Val34Leu polymorphism is associated with the development of early MI.We recruited 159 consecutive patients who had survived their first acute MI under the age of 36 years (mean age=32.1 ± 3.6 years, 138 were men). The control group consisted of 121 healthy individuals matched with cases for age and sex, without a family history of premature coronary heart disease (CHD). FXIII Val34Leu polymorphism was tested with polymerase chain reaction and reverse hybridization. There was a lower prevalence of carriers of the Leu34 allele in patients than in controls (30.2 vs. 47.1%, p=0.006). FXIII Val34Leu polymorphism was associated with lower risk for acute MI after adjusting for major cardiovascular risk factors (odds ratio [OR] = 0.51, 95% confidence interval [CI] 0.27–0.95, p=0.03). Subgroup analysis according to angiographic findings (“normal” coronary arteries [n=29] or significant CHD [n=130]) showed that only patients with MI and significant CHD had lower prevalence of carriers of the Leu34 allele compared to controls after adjusting for major cardiovascular risk factors (OR = 0.42, 95% CI 0.22–0.83, p=0.01). Our data indicate that FXIII Val34Leu polymorphism has a protective effect against the development of MI under the age of 36 years, particularly in the setting of significant CHD.