Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response
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DOI：
10.1002/jso.10321
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发表时间：
2003-12-01
影响因子：
2.5
通讯作者：
Katoh, H
中科院分区：
文献类型：
--
作者：
Oshikiri, T;Miyamoto, M;Katoh, H
背景和目的：肿瘤浸润淋巴细胞是宿主防御肿瘤扩张的重要方面。CD8(+) T细胞已被确定为几种癌症的预后因素。在这里，我们研究CD8(+) T细胞对肝外胆管癌（EBDC）患者生存的影响。方法：观察58例手术切除的EBDC标本的CD8(+) T细胞免疫反应性。分析CD8(+) T细胞免疫反应性与临床和组织病理特征的关系。结果：32例（55%）肿瘤具有CD8(+) T细胞。肿瘤内CD8(+) T细胞免疫反应程度与淋巴结转移数量减少、静脉侵袭减少、神经周围侵袭减少和pTNM分期改善有显著关系。瘤内CD8(+) T细胞也与患者生存率增加有关。多因素分析表明，肿瘤内CD8(+) T细胞的存在是一个独立的预后因素。结论：CD8(+) T细胞浸润癌细胞巢是预测EBDC患者生存率增加的可靠指标。(C) 2003 Wiley-Liss, Inc。
Background and Objectives: Tumor-infiltrating lymphocytes form an important aspect of the host defense against an expanding neoplasm. CD8(+) T cells have been identified as a prognostic factor in several cancers. Here, we investigate that the influence of CD8(+) T cells on extrahepatic bile duct carcinoma (EBDC) patient survival.Methods: CD8(+) T cell immunoreactivity in 58 surgically resected EBDC specimens was investigated. The relationship between CD8(+) T cell immunoreactivity and clinical and histopathologic features was analyzed.Results: Thirty-two tumors (55%) possessed intratumoral CD8(+) T cells. The degree of intratumoral CD8(+) T cell immunoreactivity demonstrated a significant relationship to lower numbers of lymph node metastasis, reduced venous invasion, decreased perineural invasion, and better pTNM staging. Intratumoral CD8(+) T cells were also associated with increased patient survival. Multivariate analysis indicated that the presence of intratumoral CD8(+) T cells was an independent prognostic factors.Conclusions: The infiltration of a cancer cell nest by CD8(+) T cells is a reliable marker predicting increased survival of patients with EBDC. (C) 2003 Wiley-Liss, Inc.