Apomorphine and levodopa in Parkinson's disease: Two revolutionary drugs from the 1950's
Apomorphine and levodopa in Parkinson's disease: Two revolutionary drugs from the 1950's
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DOI：
10.1016/j.parkreldis.2016.12.004
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发表时间：
2016-12-01
影响因子：
4.1
通讯作者：
Poewe, Werner
中科院分区：
文献类型：
--
作者：
Djamshidian, Atbin;Poewe, Werner
本文回顾了阿朴吗啡和左旋多巴的历史，这两种药物都是在20世纪50年代S时期发现的，并对帕金森病的治疗模式产生了革命性的影响。虽然左旋多巴的发现是基础神经科学成功转化为临床常规的一个典型例子，但阿朴吗啡的历史建立在较少的确凿证据基础上。尽管如此，在第一次临床实验60多年后，这两种药物仍然是治疗帕金森氏症患者最有效的两种药物。目前正在研究左旋多巴和阿朴吗啡的新的和有希望的给药策略，以进一步改善临床反应。(C)2016爱思唯尔有限公司。保留所有权利。
This article reviews the history of apomorphine and levodopa, which were both discovered in the 1950's and have revolutionized treatment paradigms of Parkinson's disease. Although the discovery of levodopa is a prime example of successful translation of basic neuroscience into clinical routine, the history of apomorphine was based on less solid evidence.Despite this, both drugs are, more than 6 decades after the first clinical experiments, still the two most efficacious medications to treat patients with Parkinson's disease. New and promising delivery strategies for both levodopa and apomorphine are currently under investigation to further improve clinical responses. (C) 2016 Elsevier Ltd. All rights reserved.