DIFFERENT SUSCEPTIBILITIES TO CEREBRAL INFARCTION IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND NORMOTENSIVE SPRAGUE-DAWLEY RATS
DIFFERENT SUSCEPTIBILITIES TO CEREBRAL INFARCTION IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND NORMOTENSIVE SPRAGUE-DAWLEY RATS
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DOI：
10.1161/01.str.17.3.520
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发表时间：
1986-05-01
期刊：
影响因子：
8.3
通讯作者：
COYLE, P
中科院分区：
文献类型：
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作者：
COYLE, P
采用快速阻断5~6周龄大鼠大脑中动脉(MCA)的方法，观察侧支循环对幼年自发性高血压大鼠(SHR)和正常血压SD大鼠(SD)脑梗塞的保护作用。在大脑中动脉结扎和伊文思蓝注射后3d处死大鼠。与SD相比，SHR在大脑中动脉闭塞前血压升高，大脑皮质大面积梗死，伊文思蓝标记，以及大脑中动脉闭塞的对侧运动障碍。SHR没有形成足够的侧支循环，但它保护了SD免于脑梗塞。由于脑损伤发生在高血压形成之前的年轻自发性高血压大鼠身上，因此脑梗塞的易感性增加并不是继发性的。由于血压正常的大鼠在大脑中动脉突然闭塞后通常不会发生脑梗塞，脑梗塞的特点可能与自发性高血压大鼠血压升高的机制有关。
Rapid occlusion of the middle cerebral artery (MCA) was undertaken in 5-6 week old rats to determine whether or not the young spontaneously hypertensive rat (SHR) or the normotensive Sprague-Dawley rat (SD) is protected against cerebral infarction by collateral circulation. Rats were killed 3 days after MCA occlusion and administration of Evans blue. As compared to SD, the SHR had elevated blood pressure prior to MCA occlusion, large cortical infarcts marked with Evans blue, and motor deficits contralateral to the occluded MCA. SHR did not develop an adequate collateral circulation, but SD were protected from infarction by it. Because the cerebral lesions were in young spontaneously hypertensive rats living prior to the established form of hypertension, the increased susceptibility to infarction was not secondary to it. Since normotensive rats usually do not infarct after sudden MCA occlusion, the infarction trait may be linked to the mechanism causing elevated blood pressure in spontaneously hypertensive rats.