In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy
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DOI：
10.1002/mds.20668
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发表时间：
2006-01-01
影响因子：
8.6
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
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作者：
Gerhard, A;Trender-Gerhard, I;Brooks, DJ
进行性核上性麻痹（PSP）是一种神经退行性疾病，表现为随意凝视困难、早期福尔斯和帕金森综合征。与细胞内神经元缠结和活化的小胶质细胞相关的神经元损失被发现靶向基底神经节、脑干核和额叶皮质。（C-11]（R）-PK 11195 PET是由活化的小胶质细胞表达的外周苯二氮卓类结合位点（PBBS）的标志物。我们使用[C-11]（R）-PK 11195 PET在体内证实了4例PSP患者对退行性过程的神经胶质反应的程度和分布。与正常年龄匹配的对照组相比，PSP患者组显示基底神经节、中脑、额叶和小脑中的平均（C-11]（R）-PK 11195结合显著增加。其中两名患者在6至10个月后重新扫描，在此期间，小胶质细胞活化水平保持稳定。[C-11]（R）-PK 11195 PET显示PSP患者中涉及皮质和皮质下区域的小胶质细胞活化增加的模式，与已知的神经病理学变化分布非常一致。因此，[C-11]（R）-PK 11195 PET可能有助于在体内表征PSP中的潜在疾病活性。(C)2005年，任上海市人民政府副市长。
Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. (C-11](R)-PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [C-11](R)-PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age-matched controls, the PSP patient group showed significantly increased mean (C-11](R)-PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [C-11](R)-PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [C-11](R)-PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP. (C) 2005 Movement Disorder Society.