Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.
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DOI：
10.1038/nature12358
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发表时间：
2013-08-29
期刊：
影响因子：
64.8
通讯作者：
Morrisey, Edward E.
中科院分区：
文献类型：
--
作者：
Peng, Tien;Tian, Ying;Boogerd, Cornelis J.;Lu, Min Min;Kadzik, Rachel S.;Stewart, Kathleen M.;Evans, Sylvia M.;Morrisey, Edward E.
心血管系统和肺系统的共同发展是最近对陆地生命的进化适应，将心输出量与肺的气体交换功能相结合。在这份报告中，我们表明，肺血管的发展，即使在没有肺的发展。我们已经确定了一个人口的多能心肺中胚层祖细胞（CPPs）内的心脏后极，标志着Wnt 2/Gli 1/Isl 1的表达。我们发现，CPPs产生于肺发育之前的心脏祖细胞。谱系追踪和克隆分析表明，CPP在心脏流入道和肺内产生中胚层谱系，包括心肌细胞、肺血管和气道平滑肌、近端血管内皮和周细胞样细胞。CPP受来自前肠内胚层的hedgehog表达调节，这是肺血管系统与心脏连接所需的。总之，这些研究确定了一种新的多能心肺祖细胞群体，该群体协调适应陆地生存所需的心脏和肺共同发育。
Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung . In this report, we show that the pulmonary vasculature develops even in the absence of lung development. We have identified a population of multi-potent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2/Gli1/Isl1. We show that CPPs arise from cardiac progenitors prior to lung development. Lineage tracing and clonal analysis demonstrates that CPPs generate the mesoderm lineages within the cardiac inflow tract and lung including cardiomyocytes, pulmonary vascular and airway smooth muscle, proximal vascular endothelium, and pericyte-like cells. CPPs are regulated by hedgehog expression from the foregut endoderm, which is required for connection of the pulmonary vasculature to the heart. Together, these studies identify a novel population of multipotent cardiopulmonary progenitors that coordinates heart and lung co-development that is required for adaptation to terrestrial existence.
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