Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves
Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves
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DOI：
10.1016/j.compfluid.2018.01.037
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发表时间：
2018-04-30
影响因子：
2.8
通讯作者：
Alexiadis, A.
中科院分区：
文献类型：
--
作者：
Ariane, M.;Vigolo, D.;Alexiadis, A.
栓子是血凝块的一部分，可以卡在各种器官（最常见的是肺）的脉管系统中，并导致其功能障碍甚至死亡。在这项工作中，使用数学建模，不同类型的栓塞样结构进行了研究，在一个双静脉瓣膜系统。该模型采用完全拉格朗日离散多物理技术，流动由柔性壁控制。该研究显示了瓣膜周围血流中自由栓子的不同直径和长度的影响。栓子的存在强烈影响静脉瓣膜中的流体和小叶的动力学，并且栓子在瓣膜腔室中的持久性与其长度密切相关。(C)2018爱思唯尔有限公司版权所有。
Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length. (C) 2018 Elsevier Ltd. All rights reserved.