TIACUMICINS, A NOVEL COMPLEX OF 18-MEMBERED MACROLIDES .2. ISOLATION AND STRUCTURE DETERMINATION
TIACUMICINS, A NOVEL COMPLEX OF 18-MEMBERED MACROLIDES .2. ISOLATION AND STRUCTURE DETERMINATION
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DOI：
10.7164/antibiotics.40.575
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发表时间：
1987-05-01
影响因子：
3.3
通讯作者：
MCALPINE, JB
中科院分区：
文献类型：
--
作者：
HOCHLOWSKI, JE;SWANSON, SJ;MCALPINE, JB
从桔黄孢囊菌（Daclamposporangium aurantiacum subsp.）的发酵液和菌丝体中分离到一种新的革兰氏阳性抗生素复合物。哈姆登亚种采用UV、MS、IR以及广泛的1D和2D同核和异核NMR实验推断了这六个化合物的结构。每个组分含有高度不饱和的18元大环内酯环。组分之间的差异在于大环内酯环的微小结构变化以及糖苷结合糖的数量和酯化模式。
A novel complex of Gram-positive antibiotics has been isolated from the fermentation broth and mycelium of Dactylosporangium aurantiacum subsp. hamdenensis subsp. nov. The structures of these six compounds were deduced employing UV, MS, IR, and extensive 1D and 2D homonuclear and heteronuclear NMR experiments. Each component contained a highly unsaturated 18-membered macrolide ring. Components differed from one another by minor structural variations in the macrolide ring and by the number and esterification pattern of glycosidically bound sugars.