End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation
End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation
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DOI：
10.1002/mds.20896
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发表时间：
2006-08-01
影响因子：
8.6
通讯作者：
Tarsy, Daniel
中科院分区：
文献类型：
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作者：
Apetauerova, Diana;Ryan, R. Kevin;Tarsy, Daniel
我们报告了深部脑刺激 (DBS) 对 2 名帕金森病 (PD) 患者的治疗效果，该患者患有严重的剂量结束运动障碍且对药物治疗有抵抗力。当当天最后一剂左旋多巴剂量逐渐消失时，这两名患者都出现了严重的弹道运动障碍。 1 例苍白球 (GPi) DBS 和第二例丘脑 (STN) DBS 使日终运动障碍完全缓解。 (C) 2006 年运动障碍协会。
We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia. (C) 2006 Movement Disorder Society.