EFFECTS OF AGONISTS AND ANTAGONISTS OF D1 AND D2 DOPAMINE-RECEPTORS ON SELF-STIMULATION OF THE MEDIAL PREFRONTAL CORTEX IN THE RAT
EFFECTS OF AGONISTS AND ANTAGONISTS OF D1 AND D2 DOPAMINE-RECEPTORS ON SELF-STIMULATION OF THE MEDIAL PREFRONTAL CORTEX IN THE RAT
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DOI：
10.1016/0091-3057(83)90041-2
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
MORA, F
中科院分区：
文献类型：
--
作者：
FERRER, JMR;SANGUINETTI, AM;MORA, F
本文研究了大鼠内侧前额叶皮层（MPC）D_1和D_2多巴胺[DA]受体在介导自我刺激（SS）的多巴胺能神经传递中的可能作用。使用DA受体激动剂和拮抗剂的脑内[i. c]以及i. p.注射。在全身注射进行的所有实验中，平行于SS行为测量自发运动活动（SM），作为药物非特异性作用的对照。I.C.单侧注射，对侧SS（未注射或注射0.9%NaCl）作为相同动物的对照。使用螺哌利多和匹莫齐特作为D1-D2 DA拮抗剂，而舒必利作为特异性D2拮抗剂。阿扑吗啡被用作D1-D2激动剂，而溴隐亭和麦角腈的使用剂量被认为主要是D2激动剂。舒必利i. p.或i.c.在刺激电极所在的同一部位注射对SS没有影响。D1-D2拮抗剂螺哌利多和匹莫齐特i. p.或i.c.注射产生了剂量依赖性的减少SS。[阿扑吗啡对SS产生剂量相关性降低，对SM产生低剂量降低和高剂量增加。溴隐亭和麦角腈对SS无影响，对SM呈剂量相关性降低。]显然，参与MPC SS的DA神经传递是通过D1 DA受体介导的。
The possible participation of D1 vs. D2 dopamine [DA] receptors in mediating dopaminergic neurotransmission of self-stimulation (SS) in the medial prefrontal cortex (MPC) of the rat was studied. Intracerebral [i.c] as well as i.p. injections of agonists and antagonists of DA receptors were used. In all experiments performed with systemic injections, spontaneous motor activity (SM) was measured parallel to SS behavior as control for non-specific effects of the drugs. I.c. injections were done unilaterally serving SS of the contralateral side (not injected or injected with 0.9% NaCl) as control in the same animals. Spiroperidol and pimozide were used as D1-D2 DA antagonists while sulpiride was used as a specific D2 antagonist. Apomorphine was used as D1-D2 agonist while bromocriptine and lergotrile were used at doses in which these ergot drugs are considered predominantly D2 agonists. Sulpiride i.p. or i.c. injected at the same locus at which the stimulating electrode was located produced no effect on SS. The D1-D2 antagonists spiroperidol and pimozide i.p. or i.c. injected produced a dose-dependent decrease on SS. [Apomorphine produced a dose-related decrease on SS and a decrease at lower doses and an increase at higher doses on SM. Bromocriptine and lergotrile had no effect on SS and a dose-related decrease on SM.] Apparently, DA neurotransmission involved in SS of the MPC is mediated via D1 DA receptors.