Increased plasma 8-isoprostane levels in hypertensive subjects: The Tsurugaya project
Increased plasma 8-isoprostane levels in hypertensive subjects: The Tsurugaya project
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DOI：
10.1291/hypres.27.557
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发表时间：
2004-08-01
影响因子：
5.4
通讯作者：
Tsuji, I
中科院分区：
文献类型：
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作者：
Hozawa, A;Ebihara, S;Tsuji, I
为了研究8-异前列腺素与血压之间的关系，我们测量了日本老年人血浆8-异前列腺素浓度和家庭血压水平。我们的研究人群包括569名年龄在70岁及以上且未接受抗高血压药物治疗的受试者。根据他们的血压值，参与者被分为三组：正常（家庭血压< 135/85 mmHg），高血压（家庭血压135/85-160/90 mmHg）和严重高血压（家庭血压大于或等于160/90 mmHg）。重度高血压组的平均血浆8-异前列腺素水平（21.1 +/- 5.2 pg/ml）显著高于正常组（20.2 +/- 4.9 pg/ml）或高血压组（19.7 +/- 5.1 pg/ml），并且当我们调整了可能的混杂因素，如年龄、性别、使用维生素A、C或E补充剂、吸烟状况、饮酒状况、体重指数、使用非甾体类抗炎药、糖尿病史、高胆固醇血症、家庭心率和血清肌酐水平。因此，血浆8-异前列腺素水平似乎在老年重度高血压患者中升高。
To examine the relationship between 8-isoprostane and blood pressure, we measured plasma 8-isoprostane concentration and home blood pressure levels in an elderly Japanese population. Our study population comprised 569 subjects aged 70 years and over who were not receiving antihypertensive medication. On the basis of their blood pressure values, the participants were classified into three groups: normotensive (home blood pressure < 135/85 mmHg), hypertensive (home blood pressure 135/85-160/90 mmHg), and severely hypertensive (home blood pressure greater than or equal to160/90 mmHg). The mean plasma 8-isoprostane level in the severely hypertensive group (21.1 +/- 5.2 pg/ml) was significantly higher than that in the normotensive (20.2 +/- 4.9 pg/ml) or hypertensive (19.7 +/- 5.1 pg/ml) group, and this result was unchanged when we adjusted for possible confounding factors such as age, sex, use of vitamin A, C or E supplements, smoking status, drinking status, body mass index, use of non-steroidal anti-inflammatory drugs, history of diabetes, hypercholesterolemia, home heart rate and serum creatinine level. Thus, the level of plasma 8-isoprostane appears to be elevated in older subjects with severe hypertension.