Unveiling the Genetic Architecture of Human Disease for Precision Medicine.
Unveiling the Genetic Architecture of Human Disease for Precision Medicine.
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揭示精准医学人类疾病的遗传结构。
DOI：
10.1111/cts.12593
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Karnes,Jason
中科院分区：
文献类型：
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作者：
Ramamoorthy,Anuradha;Yee,SookWah;Karnes,Jason
这篇评论强调了在佛罗里达奥兰多举行的2018年美国临床药理学和治疗学学会年会（ASCPT）上题为“为精准医学揭开人类疾病的遗传结构”的研讨会的会议记录。重点是基因组学和药物基因组学，本次会议重点讨论了利用人类遗传学来确定新的药物靶点，利用药物基因组学研究改善获益和风险评估，以及在药物开发过程中考虑不同种族/民族人群等位基因频率差异的重要性。
This Commentary highlights proceedings from the workshop titled “Unveiling the Genetic Architecture of Human Disease for Precision Medicine” at the 2018 American Society for Clinical Pharmacology and Therapeutics Annual Meeting (ASCPT) in Orlando, Florida. With an emphasis on genomics and pharmacogenomics, this session focused on use of human genetics to identify new drug targets, improving assessment of benefit and risk using pharmacogenomics studies, and importance of considering differences in allele frequency across racial/ethnic populations during drug development.