Early Diagnosis of Pancreatic Cancer Using Endoscopic Ultrasound
Early Diagnosis of Pancreatic Cancer Using Endoscopic Ultrasound
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DOI：
10.1007/978-981-10-2486-3_1
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
S. Hijioka;K. Yamao;N. Mizuno;H. Imaoka;V. Bhatia;K. Hara
中科院分区：
文献类型：
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作者：
S. Hijioka;K. Yamao;N. Mizuno;H. Imaoka;V. Bhatia;K. Hara
胰腺癌虽然发病率低，但死亡率却很高。早期发现并根据不同的影像表现选择合适的治疗方法是提高PC患者生存率的关键。多探测器(MD)行计算机断层扫描(CT)是目前全球评估PC的标准成像方式。然而，10%的PC肿瘤在CT上是等密度的，因此是不可见的，特别是当≤为2 cm时。超声内窥镜(EUS)可以比CT更快地发现10厘米以下的肿瘤，对诊断高度恶性的胰腺上皮内瘤变(PanIN3)和磁共振胆胰管成像可能是有用的，因为它们都可以发现胰腺导管的局部不规则狭窄。由于胰腺癌的发生率较低，基于人口的筛查是不可行的，但对于高危患者是可取的，在这些患者中可以用EUS发现癌前病变。最近引入的新技术，如对比增强EUS和弹性成像可能会提高EUS的准确性。我们回顾了EUS在早期PC检测和诊断中的作用。
Despite a low incidence, the mortality rate of pancreatic cancer (PC) is high. Early detection and optimal treatment based on the findings of various imaging modalities are essential to improve the survival rate of patients with PC. Multi-detector (MD) row computed tomography (CT) is currently the standard imaging modality for evaluating PC worldwide. However, 10% of PC tumors can be iso-attenuated on CT and thus invisible, especially when ≤2 cm. Endoscopic ultrasonography (EUS) can detect tumors that are <10 cm at a higher rate than CT and might be useful for diagnosing high-grade pancreatic intraepithelial neoplasia (PanIN3) as well as magnetic resonance cholangiopancreatography, as they can both detect local irregular stenosis of the pancreatic duct.Population-based screening is not feasible due to the low incidence of PC, but it is advisable for high-risk patients, in whom premalignant lesions can be detected using EUS.The introduction of recent novel techniques such as contrast-enhanced EUS and elastography might improve the accuracy of EUS.We reviewed the role of EUS in the detection and diagnosis of early-stage PC.