Intravitreal bevacizumab injections versus verteporferin photodynamic therapy for macular choroidal neovascularization in high myopia: 24-month follow-up
Intravitreal bevacizumab injections versus verteporferin photodynamic therapy for macular choroidal neovascularization in high myopia: 24-month follow-up
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DOI：
10.1016/j.jfo.2012.03.015
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发表时间：
2013-01-01
影响因子：
1.2
通讯作者：
Basaraih, S.
中科院分区：
文献类型：
--
作者：
El Matri, L.;Chebil, A.;Basaraih, S.
目的. - 比较玻璃体内注射贝伐单抗（IVB）和维替泊苷光动力疗法（PDT）治疗高度近视患者脉络膜新生血管（CNV）的长期安全性和安全性。- 回顾性收集的60例高度近视脉络膜新生血管患者的60只眼的数据，这些患者接受标准PDT（PDT组; n = 30）或IVB注射（IVB组; n = 30）治疗。比较两组患者治疗前、治疗后3、6、12、24个月的疗效。- 在IVB组中，平均最佳矫正视力（BCVA）在3至12个月时显著改善;然而，在24个月时失去了显著性。PDT组在3个月和6个月时表现出不明显的改善，然后在12个月和24个月时恶化。在3、6、12和24个月时，IVB组的平均BCVA优于PDT组。在3、6、12和24个月时，IVB组的平均中央黄斑厚度的降低显著高于PDT组。24个月时，IVB组5只眼（16.6%）和PDT组22只眼（73.3%）出现脉络膜视网膜萎缩（P = 2x 10（-5））。- 长期来看，IVB对高度近视CNV的BCVA显著优于PDT。(C)2012年Elsevier Masson SAS。All rights reserved.
Purpose. - To compare the long-term safety and of intravitreal bevacizumab injections (IVB) and verteporferin photodynamic therapy (PDT) in the treatment of choroidal neovascularization (CNV) in high myopia.Methods. - Review of retrospectively collected data of 60 eyes of 60 patients with high myopic choroidal neovascularization treated either with standard PDT (PDT group; n = 30) or IVB injections (IVB group; n = 30). The two groups were compared at baseline, 3, 6,12 and 24 months.Results. - In the IVB group, mean best corrected visual acuity (BCVA) was significantly improved at 3 to 12 months; however, the significance was lost at 24 months. The PDT group showed an insignificant improvement at 3 and 6 months, then worsened at 12 and 24 months. Mean BCVA was better in the IVB group than the PDT group at 3, 6, 12 and 24 months. The decrease in mean central macular thickness was significantly higher in the IVB group than in the PDT group at 3, 6, 12 and 24 months. At 24 months, chorioretinal atrophy was noted in five eyes (16.6%) treated with IVB and in 22 eyes (73.3%) treated with PDT (P = 2x10(-5)).Conclusion. - IVB provides significantly better BCVA than PDT for high myopic CNV over the long-term. (C) 2012 Elsevier Masson SAS. All rights reserved.