Autologous Chondrocyte Implantation of the Ankle
Autologous Chondrocyte Implantation of the Ankle
复制标题
踝关节自体软骨细胞植入
DOI：
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发表时间：
2014
影响因子：
4.8
通讯作者：
G. Applegate
中科院分区：
文献类型：
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作者：
Steve K Kwak;Brian S Kern;R. Ferkel;K. W. Chan;Sina Kasraeian;G. Applegate
背景：手术失败后距骨软骨损伤的治疗具有挑战性，没有明确的解决方案。使用自体软骨细胞植入的短期结果是有希望的。目的：报告骨髓刺激技术治疗距骨软骨病（OLT）失败后接受距骨自体软骨细胞植入（ACI）的患者的长期结局。研究设计：病例系列;证据等级，4。研究方法：32名连续患者接受了距骨ACI，29名患者（15名男性，14名女性;平均年龄，34岁[范围，16-54岁]）可接受随访。有23处内侧病变和6处外侧病变，平均尺寸为18 × 11 mm（198 mm 2;范围，80-500 mm 2）。20例患者仅接受了距骨ACI; 9例患者接受了ACI并对下方囊肿进行了植骨。平均随访70个月（范围：24-129个月）。使用简化的足踝评分、Tegner活动评分、Finsen评分和美国足踝矫形协会（AOFAS）踝-后足评分评价患者结局。25名患者（86%）在取出内固定器械时接受了二次关节镜手术，并使用国际腕关节修复学会（ICRS）评分进行了评估。对24例患者（83%）进行了术后磁共振成像（MRI），并与术前MRI扫描进行了比较。结果：术前，26例患者使用简化踝关节评分将其踝关节评定为差，3例评定为可。在末次随访时，使用相同评分，9例被分类为优，14例为良，5例为可，1例为差。平均AOFAS评分从50.1改善至85.9（范围，65-100）。平均Tegner活动评分从1.6改善至4.3（P < .0001）。平均Finsen评分（改良Weber评分）显示从13.7显著改善至5.1（P <0.0001）。结论：自体软骨细胞植入距骨可改善所有测试参数，并在既往OLT手术失败的患者中获得持久的长期结果。
Background: The treatment of osteochondral lesions of the talus after failed surgery is challenging, with no clear solution. Short-term results using autologous chondrocyte implantation have been promising. Purpose: To report the long-term outcomes of patients who underwent autologous chondrocyte implantation (ACI) of the talus after failed marrow stimulation techniques for osteochondral lesions of the talus (OLTs). Study Design: Case series; Level of evidence, 4. Methods: Thirty-two consecutive patients underwent ACI of the talus, and 29 patients (15 male, 14 female; mean age, 34 years [range, 16-54 years]) were available for follow-up. There were 23 medial and 6 lateral lesions, with a mean size of 18 × 11 mm (198 mm2; range, 80-500 mm2). Twenty patients underwent ACI of the talus alone; 9 underwent ACI with bone grafting of underlying cysts. Follow-up was performed at a mean of 70 months (range, 24-129 months). Patient outcomes were evaluated using the simplified symptomatology score, Tegner activity score, Finsen score, and American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score. Twenty-five patients (86%) underwent second-look arthroscopic surgery at the time of hardware removal and were assessed with the International Cartilage Repair Society (ICRS) score. Postoperative magnetic resonance imaging (MRI) was performed on 24 patients (83%) and compared with preoperative MRI scans. Results: Preoperatively, 26 patients rated their ankles as poor and 3 as fair using the simplified symptomatology score. At last follow-up, 9 were classified as excellent, 14 as good, 5 as fair, and 1 as poor using the same score. The mean AOFAS score improved from 50.1 to 85.9 (range, 65-100). The mean Tegner activity score improved from 1.6 to 4.3 (P < .0001). The mean Finsen score (modified Weber score) showed significant improvement from 13.7 to 5.1 (P < .0001). Conclusion: Autologous chondrocyte implantation of the talus yields improvement in all parameters tested with enduring long-term results in patients who have failed previous surgery for OLTs.
膝关节软骨修复的磁共振成像。
DOI：
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发表时间：
1998
期刊：
Topics in magnetic resonance imaging : TMRI.
影响因子：
--
作者：
Gold,GE;Bergman,AG;Pauly,JM;Lang,P;Butts,RK;Beaulieu,CF;Hargreaves,B;Frank,L;Boutin,RD;Macovski,A;Resnick,D
通讯作者：
Resnick,D
软骨细胞基质金属蛋白酶-8：人膝关节和踝关节软骨中白细胞介素-1β对中性粒细胞胶原酶的上调。
DOI：
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发表时间：
1996
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
Chubinskaya,S;Huch,K;Mikecz,K;Cs-Szabo,G;Hasty,KA;Kuettner,KE;Cole,AA
通讯作者：
Cole,AA