Strabismic suppression is mediated by inhibitory interactions in the primary visual cortex
Strabismic suppression is mediated by inhibitory interactions in the primary visual cortex
复制标题
DOI：
10.1093/cercor/bhj110
复制
发表时间：
2006-12-01
期刊：
影响因子：
3.7
通讯作者：
Eysel, Ulf T.
中科院分区：
文献类型：
--
作者：
Sengpiel, Frank;Jirmann, Kay-Uwe;Eysel, Ulf T.
大多数斜视观察者不会受到复视的困扰，因为两只眼睛中有一只眼睛相互冲突的观点受到了有意识的抑制。斜视抑制的部位和神经底物的直接证据到目前为止还没有得到，尽管心理物理数据表明起源于皮质。另一方面，单眼呈现的相互冲突的刺激之间的交叉方向抑制最近被证明具有很强的丘脑成分。在这里，我们提出了证据，使用视觉刺激和药理学技术，斜视抑制发生在初级视觉皮质，并涉及伽马氨基丁酸(GABA)介导的抑制。我们表明，它对抑制刺激漂移率的依赖与皮层起源是一致的；与单眼交叉定向抑制不同，它不能被非常快移动的刺激诱发。此外，当GABA(A)拮抗剂荷包牡丹碱局部阻断GABA能抑制时，斜视抑制大大减少。
Most strabismic observers do not suffer from double vision because of suppression from conscious perception of 1 of the 2 eyes' conflicting views. Direct evidence for the site and neural substrate of strabismic suppression has not been available so far, although psychophysical data suggest a cortical origin. On the other hand, cross-orientation suppression among conflicting stimuli presented monocularly has recently been shown to have a strong thalamic Component. Here we present evidence, using both visual stimulation and pharmacological techniques, that strabismic suppression occurs in the primary visual cortex and involves gamma-amino butyric acid (GABA)-mediated inhibition. We show that its dependency on the drift rate of the suppressing stimulus is consistent with a cortical origin; unlike monocular cross-orientation suppression, it cannot be evoked by very fast-moving stimuli. Furthermore, strabismic suppression is greatly reduced when GABAergic inhibition is locally blocked by the GABA(A) antagonist bicuculline.