GLUCAGON, CATECHOLAMINE AND PANCREATIC-POLYPEPTIDE SECRETION IN TYPE-I DIABETIC RECIPIENTS OF PANCREAS ALLOGRAFTS
GLUCAGON, CATECHOLAMINE AND PANCREATIC-POLYPEPTIDE SECRETION IN TYPE-I DIABETIC RECIPIENTS OF PANCREAS ALLOGRAFTS
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DOI：
10.1172/jci114936
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发表时间：
1990-12-01
影响因子：
15.9
通讯作者：
ROBERTSON, RP
中科院分区：
文献类型：
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作者：
DIEM, P;REDMON, JB;ROBERTSON, RP
1型糖尿病患者成功的胰腺移植恢复了正常的空腹血糖水平和对葡萄糖的双相胰岛素反应。然而，实际上没有来自胰腺接受者的相对于其他胰岛激素反应或低血糖激素反调节的数据。因此，葡萄糖，胰高血糖素，儿茶酚胺，和胰腺多肽的反应，胰岛素诱导的低血糖和刺激精氨酸和胰泌素进行了检查，在38个糖尿病胰腺受体，54个I型糖尿病nonrecipients，和26个非糖尿病正常对照组。胰岛素诱导的低血糖后胰腺受体的葡萄糖恢复显着改善。接受者的基础胰高血糖素水平显著高于非接受者和正常受试者。胰高血糖素对胰岛素诱导的低血糖的反应在胰腺接受者中显著高于非接受者，并且与对照受试者中观察到的相似。 胰高血糖素对静脉精氨酸的反应在胰腺受体中显著大于在非受体和正常受试者中观察到的。在胰岛素诱导的低血糖期间，未观察到肾上腺素反应的差异。当比较受体组和非受体组时，没有观察到胰腺多肽对低血糖的反应差异，两者均低于对照组。我们的数据表明，在I型糖尿病胰腺移植受者中，低血糖后血糖恢复显著改善，这与胰高血糖素分泌改善有关。
Successful pancreas transplantation in type I diabetic patients restores normal fasting glucose levels and biphasic insulin responses to glucose. However, virtually no data from pancreas recipients are available relative to other islet hormonal responses or hormonal counterregulation of hypoglycemia. Consequently, glucose, glucagon, catecholamine, and pancreatic polypeptide responses to insulin-induced hypoglycemia and to stimulation with arginine and secretin were examined in 38 diabetic pancreas recipients, 54 type I diabetic nonrecipients, and 26 nondiabetic normal control subjects. Glucose recovery after insulin-induced hypoglycemia in pancreas recipients was significantly improved. Basal glucagon levels were significantly higher in recipients compared with nonrecipients and normal subjects. Glucagon responses to insulin-induced hypoglycemia were significantly greater in the pancreas recipients compared with nonrecipients and similar to that observed in control subjects. Glucagon responses to intravenous arginine were significantly greater in pancreas recipients than that observed in both the nonrecipients and normal subjects. No differences were observed in epinephrine responses during insulin-induced hypoglycemia. No differences in pancreatic polypeptide responses to hypoglycemia were observed when comparing the recipient and nonrecipient groups, both of which were less than that observed in the control subjects. Our data demonstrate significant improvement in glucose recovery after hypoglycemia which was associated with improved glucagon secretion in type I diabetic recipients of pancreas transplantation.