Highly magnetic iron carbide nanoparticles as effective T2 contrast agents
Highly magnetic iron carbide nanoparticles as effective T2 contrast agents
复制标题
高磁性碳化铁纳米颗粒作为有效的 T2 造影剂
DOI：
10.1039/c3nr04691e
复制
发表时间：
2014-01-01
期刊：
影响因子：
6.7
通讯作者：
Gao, Jinhao
中科院分区：
文献类型：
--
作者：
Huang, Guoming;Hu, Juan;Gao, Jinhao
本文报道了具有高空气稳定性和强饱和磁化强度的碳化铁纳米粒子可以作为磁共振成像的有效T-2造影剂。 Fe5C2纳米粒子（直径约20 nm）表现出强烈的对比度增强，r(2)值为283.2 mM(-1) S-1，大约是球形Fe3O4纳米粒子（约140.9 mM(-1) S-1）的两倍。体内实验表明，Fe5C2 纳米粒子能够在活体受试者中产生比传统 Fe3O4 纳米粒子更显着的 MRI 对比度增强，这在生物医学应用中具有广阔的前景。
This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T-2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (similar to 20 nm in diameter) exhibit strong contrast enhancement with an r(2) value of 283.2 mM(-1) S-1, which is about twice as high as that of spherical Fe3O4 nanoparticles (similar to 140.9 mM(-1) S-1). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications.