SMOKING AND CORONARY ATHEROSCLEROSIS: FOLLOW-UP STUDY IN CHINA
SMOKING AND CORONARY ATHEROSCLEROSIS: FOLLOW-UP STUDY IN CHINA
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吸烟与冠状动脉粥样硬化：中国的后续研究
DOI：
10.1111/j.1440-1681.2008.05134.x
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发表时间：
2009-07-01
影响因子：
2.9
通讯作者：
Ma, Wen-Zhu
中科院分区：
文献类型：
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作者：
Jia, En-Zhi;Liang, Jun;Ma, Wen-Zhu
本研究的目的是探讨吸烟总量与冠状动脉粥样硬化的严重程度和死亡率之间的关系。研究人群包括1096例连续的因怀疑或已知冠状动脉粥样硬化而接受冠状动脉造影的患者（820例男性和276例女性）。进行人体测量和血浆测量（体重指数、血压和血脂、血糖和胰岛素原水平）。估计了前几年吸烟的数量。冠状动脉粥样硬化的严重程度由Gensini评分系统定义。在基线时，吸烟数量与Gensini评分之间存在显著正相关（r = 0.213; P = 0.000），胰岛素原（r = 0.072; P = 0.017），白细胞总数（r = 0.179; P = 0.000）和中性粒细胞计数吸烟量与高密度脂蛋白胆固醇呈负相关（r = 0.164，P = 0.000）当参与者根据基线吸烟数量分为五类时，在考克斯比例风险模型的多变量分析中观察到基线吸烟数量与全因死亡率之间的独立关联，风险比为在中位随访2.86年期间，吸烟量为1.328（1.086-1.623; P = 0.006），吸烟数量是中国人群中冠状动脉粥样硬化的高度显著预测因子，也是动脉粥样硬化患者死亡的独立危险因素。
P>The aim of the present study was to explore the association between the total number of cigarettes smoked in life and the severity of and mortality due to coronary atherosclerosis.The study population comprised 1096 consecutive patients (820 men and 276 women) who underwent coronary angiography for suspected or known coronary atherosclerosis. Anthropometric and plasma measurements (body mass index, blood pressure and blood lipid, blood glucose and pro-insulin levels) were made. The number of cigarettes smoked during previous years was estimated. The severity of coronary atherosclerosis was defined by the Gensini score system.At baseline, a significant positive association was observed between the number of cigarettes smoked and Gensini score (r = 0.213; P = 0.000), pro-insulin (r = 0.072; P = 0.017), total leucocyte count (r = 0.179; P = 0.000) and neutrophil count (r = 0.164; P = 0.000), whereas an inverse correlation was found between the number of cigarettes smoked and High-density lipoprotein-cholesterol (r = -0.150; P = 0.000).When participants were divided into five categories based on the baseline number of cigarettes smoked, an independent association between baseline number of cigarettes smoked and all-cause mortality was observed in a multivariate analysis of Cox proportional hazards models, with a hazard ratio (95% confidence interval) of 1.328 (1.086-1.623; P = 0.006) during a median follow up of 2.86 years.The number of cigarettes smoked was a highly significant predictor of coronary atherosclerosis and an independent risk factor for mortality in subjects with atherosclerosis in this Chinese population.