Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
复制标题
DOI：
10.1242/jcs.045112
复制
发表时间：
2010-04-01
影响因子：
4
通讯作者：
Schaller, Michael D.
中科院分区：
文献类型：
--
作者：
Schaller, Michael D.
粘着斑激酶(FAK)和富含脯氨酸的酪氨酸激酶2(PYK2)是相关的酪氨酸激酶，具有重要的细胞功能，主要通过调节细胞骨架发挥作用。最近的研究已经确定了调节细胞骨架反应的多种分子机制，并为FAK和Pyk2如何控制细胞迁移等细胞过程提供了重要而令人兴奋的见解。同样令人兴奋的是关于这些激酶的新颖的和最初没有预料到的功能的报道，为未来的研究途径提供了基础。这篇评论总结了一些最近的发现，这些发现与细胞的生物反应控制有关。
Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are related tyrosine kinases that have important cellular functions, primarily through regulation of the cytoskeleton. Recent studies have identified multiple molecular mechanisms that regulate cytoskeletal responses, and have provided important and exciting insights into how FAK and Pyk2 control cellular processes such as cell migration. Equally exciting are reports of novel and originally unanticipated functions of these kinases, providing the groundwork for future avenues of investigation. This Commentary summarizes some of these recent discoveries that are relevant to the control of biological responses of the cell.