The contribution of corticosterone and testosterone to the suppression of serum LH in hyperprolactinaemic adult male rats with pituitary transplants.
The contribution of corticosterone and testosterone to the suppression of serum LH in hyperprolactinaemic adult male rats with pituitary transplants.
复制标题
皮质酮和睾酮对垂体移植的高催乳素血症成年雄性大鼠血清 LH 抑制的作用。
作者：
R. Weber;M. Ooms;J. Vreeburg
在R × U系成年雄性大鼠中研究了高泌乳素血症对血清LH水平的影响。在每个实验的第0天，通过在肾包膜下移植三个垂体移植物诱导高泌乳素血症。特别注意了催乳素刺激的睾丸，肾上腺和皮质酮的贡献。在实验1中，高催乳素血症显着降低血清LH浓度在完整的大鼠。尽管皮质酮的血清水平显着增加，血清睾酮没有显着影响高泌乳素血症。尸检时，肾上腺和副性腺的重量均显著增加。在实验2中，皮下注射10 mg皮质酮处理垂体移植后第14天至第28天，每天均显著降低血清LH和睾酮水平。高催乳素血症皮质酮给药动物中睾酮的抑制显著低于皮质酮给药对照动物。高催乳素血症动物的副性腺重量显著增加。实验三，切除大鼠肾上腺，其中一半用皮质酮替代。高泌乳素血症肾上腺切除大鼠和肾上腺切除皮质酮治疗动物的血清睾酮水平显着增加，对血清LH无任何显着影响。高催乳素血症动物的副性腺重量再次显著增加。在实验4中，在第0天对大鼠进行肾上腺切除、性腺切除和皮质酮处理，然后植入含有睾酮的2、1.5或1 cm硅胶弹性体胶囊。（250字处删节）
The effects of hyperprolactinaemia on serum levels of LH were investigated in adult male rats of the R X U strain. Hyperprolactinaemia was induced by three pituitary grafts under the kidney capsule, transplanted on day 0 of each experiment. Special attention was paid to the contribution of prolactin-stimulated testes, adrenals and corticosterone. In experiment 1, hyperprolactinaemia significantly reduced the serum concentrations of LH in intact rats. In spite of a significant increase in the serum levels of corticosterone, serum testosterone was not significantly affected by hyperprolactinaemia. The weights of both the adrenals and accessory sex glands were significantly increased at autopsy. In experiment 2, treatment with 10 mg corticosterone s.c. daily from day 14 to day 28 after pituitary grafting significantly reduced serum levels of both LH and testosterone. The suppression of testosterone in the hyperprolactinaemic corticosterone-treated animals was significantly less than in the corticosterone-treated control animals. The weights of the accessory sex glands were significantly increased in the hyperprolactinaemic animals. In experiment 3, rats were adrenalectomized and half of them were substituted with corticosterone. Serum testosterone levels significantly increased in both hyperprolactinaemic adrenalectomized rats and in adrenalectomized corticosterone-treated animals without any significant effect on serum LH. Again the weights of the accessory sex glands were significantly increased in the hyperprolactinaemic animals. In experiment 4, rats were adrenalectomized, gonadectomized and corticosterone treated on day 0 and then implanted with a 2, 1.5 or 1 cm silicone elastomer capsule containing testosterone.(ABSTRACT TRUNCATED AT 250 WORDS)