Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine
Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine
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DOI：
10.1177/0333102416639512
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发表时间：
2017-02-01
期刊：
影响因子：
4.9
通讯作者：
Ashina, Messoud
中科院分区：
文献类型：
--
作者：
Guo, Song;Christensen, Anne Francke;Ashina, Messoud
背景：降钙素基因相关肽在65%的无先兆偏头痛患者中引起偏头痛发作。一级亲属中偏头痛的聚集（家族负荷）或大量的风险赋予单核苷酸多态性是否有助于偏头痛患者对降钙素基因相关肽输注的易感性尚不清楚。我们假设基因富集在偏头痛的触发中起作用，因此，高家庭负荷的无先兆偏头痛患者在输注降钙素基因相关肽后比低家庭负荷的患者报告更多的偏头痛发作。我们将40名先前基因分型的无先兆偏头痛患者分配接受静脉输注1.5 μ g/min降钙素基因，相关肽和记录的偏头痛发作，包括头痛特征和相关症状。通过电话采访的一级亲属使用一个有效的半结构式questionnaire.Results：降钙素基因相关肽输注诱导偏头痛样发作75%（12的16）的高家庭负荷的患者相比，52%（12的23）与低家庭负荷（P = 0.150）。此外，我们发现，降钙素基因相关肽后的偏头痛反应与特定的或大量的偏头痛无先兆的风险赋予单核苷酸多态性无aur.Conclusion：我们发现偏头痛的家族聚集性和降钙素基因相关肽输注无先兆偏头痛患者的超敏反应之间没有统计学关联。我们还证明了目前已知的单核苷酸多态性赋予无先兆偏头痛的风险对降钙素基因相关肽诱导的偏头痛样发作没有累加效应。
Background: Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and, therefore, migraine without aura patients with high family load would report more migraine attacks after calcitonin gene-related peptide infusion than patients with low family load.Methods: We allocated 40 previously genotyped migraine without aura patients to receive intravenous infusion of 1.5 mu g/min calcitonin gene-related peptide and recorded migraine attacks including headache characteristics and associated symptoms. Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire.Results: Calcitonin gene-related peptide infusion induced a migraine-like attack in 75% (12 out of 16) of patients with high family load compared to 52% (12 out of 23) with low family load (P = 0.150). In addition, we found that the migraine response after calcitonin gene-related peptide was not associated with specific or a high number of risk-conferring single nucleotide polymorphisms of migraine without aura.Conclusion: We found no statistical association between familial aggregation of migraine and hypersensitivity to calcitonin gene-related peptide infusion in migraine without aura patients. We also demonstrated that the currently known single nucleotide polymorphisms conferring risk of migraine without aura have no additive effect on calcitonin gene-related peptide induced migraine-like attacks.