Antiviral B cell and T cell immunity in the lungs.
Antiviral B cell and T cell immunity in the lungs.
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DOI：
10.1038/ni.3056
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发表时间：
2015-01
影响因子：
30.5
通讯作者：
Openshaw PJ
中科院分区：
文献类型：
--
作者：
Chiu C;Openshaw PJ
肺是大多数病毒病原体进入的主要部位。在这篇焦点综述中，Chiu和Openshaw讨论了对嗜肺病毒的适应性免疫反应及其对疫苗开发的影响。呼吸道病毒是反复发生的普通感冒、支气管炎和肺炎的常见原因，这些疾病通常以流行病和大流行病的形式不可预测地发生。尽管这些对健康的毁灭性影响和数十年的深入研究，治疗仍然在很大程度上支持。唯一普遍可用的疫苗是针对流感病毒的，即使这些疫苗也需要改进。肺与其他粘膜部位有一些共同的特征，但其特别精细的解剖结构的保存需要促炎和抗炎反应的良好平衡;适时、适当放置和严格调节的T细胞和B细胞反应对于保护免受感染和限制症状是必不可少的，而调节不良的炎症有助于组织损伤和疾病。最近在了解适应性免疫方面的进展应有助于疫苗的开发，并减少呼吸道病毒的全球影响。
The lungs are the main site of entry for most viral pathogens. In this Focus Review, Chiu and Openshaw discuss adaptive immune responses to lung-tropic viruses and implications for vaccine development. Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruses.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
6.7
作者：
Carlson CM;Turpin EA;Moser LA;O'Brien KB;Cline TD;Jones JC;Tumpey TM;Katz JM;Kelley LA;Gauldie J;Schultz-Cherry S
通讯作者：
Schultz-Cherry S
DOI：
10.1038/nri3166
发表时间：
2012-03-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.4
作者：
Chirkova, Tatiana;Boyoglu-Barnum, Seyhan;Anderson, Larry J.
通讯作者：
Anderson, Larry J.