Amino acids as regulators of gene expression at the level of mRNA translation
Amino acids as regulators of gene expression at the level of mRNA translation
复制标题
DOI：
10.1093/jn/133.6.2046s
复制
发表时间：
2003-06-01
影响因子：
4.2
通讯作者：
Kimball, SR
中科院分区：
文献类型：
--
作者：
Jefferson, LS;Kimball, SR
氨基酸通过许多信号传导途径和机制起作用，以在mRNA翻译水平介导基因表达的控制。这份报告回顾了最近的研究结果，说明了氨基酸通过何种方式发挥作用，以调节mRNA翻译的起始阶段。该报告的重点是涉及真核起始因子-2（eIF 2）蛋白激酶，一般控制非去阻遏激酶-2和雷帕霉素（mTOR）蛋白激酶的哺乳动物靶的信号通路。它还描述了氨基酸诱导的eIF 2磷酸化调节和mTOR介导的信号传导引起特异性mRNA翻译去抑制并导致基因表达模式总体变化的机制。最后，它提供了mRNAs的例子，其翻译是通过这些机制调节的。J.营养133：2046S-2051S，2003.
Amino acids act through a number of signaling pathways and mechanisms to mediate control of gene expression at the level of mRNA translation. This report reviews recent findings that illustrate the manner through which amino acids act to regulate the initiation phase of mRNA translation. The report focuses on signaling pathways that involve the eukaryotic initiation factor-2 (elF2) protein kinase, general control non-derepressing kinase-2 and the mammalian target of rapamycin (mTOR) protein kinase. It also describes the mechanisms through which amino acid-induced modulation of elF2 phosphorylation and mTOR-mediated signaling cause derepression of translation of specific mRNAs and result in an overall change in the pattern of gene expression. Finally, it provides examples of mRNAs; whose translation is modulated through these mechanisms. J. Nutr. 133: 2046S-2051S, 2003.