A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder
A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder
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DOI：
10.1177/074873002237140
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发表时间：
2002-10-01
影响因子：
3.5
通讯作者：
van den Hoofdakker, RH
中科院分区：
文献类型：
--
作者：
Koorengevel, KM;Beersma, DGM;van den Hoofdakker, RH
昼夜节律起搏器是一种内源性时钟，它以近24小时为周期调节大多数生理和心理过程的振荡。在许多物种中，这个起搏器会引发行为的季节性变化。症状的季节性和光疗的疗效提示昼夜节律起搏器参与季节性情感障碍（SAD），冬季型。本研究将SAD患者的生理起搏器特征与对照组进行比较。7名SAD患者和匹配的对照组接受了120小时的强制去同步方案，其中测量了核心体温和褪黑激素分泌情况，以表征昼夜节律起搏器参数。在该方案中，研究对象在时间隔离中暴露于6个20小时的时间内，从而能够研究暴露的昼夜节律起搏器特征。患者在冬季参加了两次（在抑郁和光疗后缓解），在夏季参加了一次。对照组在冬季和夏季各参加一次。在SAD患者和对照组之间，在褪黑激素衍生期和内源性昼夜温度节律阶段没有观察到显著差异。在抑郁和缓解的SAD患者中，这种节律的幅度明显小于对照组。在SAD患者中未观察到昼夜节律起搏器异常。体温调节过程的紊乱可能解释了SAD患者在冬季较小的昼夜温度振幅。
The circadian pacemaker is an endogenous clock that regulates oscillations in most physiological and psychological processes with a near 24-h period. In many species, this pacemaker triggers seasonal changes in behavior. The seasonality of symptoms and the efficacy of light therapy suggest involvement of the circadian pacemaker in seasonal affective disorder (SAD), winter type. In this study, circadian pacemaker characteristics of SAD patients were compared with those of controls. Seven SAD patients and matched controls were subjected to a 120-h forced desynchrony protocol, in which core body temperature and melatonin secretion profiles were measured for the characterization of circadian pacemaker parameters. During this protocol, which enables the study of unmasked circadian pacemaker characteristics, subjects were exposed to six 20-h days in time isolation. Patients participated twice in winter (while depressed and while remitted after light therapy) and once in summer. Controls participated once in winter and once in summer. Between the SAD patients and controls, no significant differences were observed in the melatonin-derived period or in the phase of the endogenous circadian temperature rhythm. The amplitude of this rhythm was significantly smaller in depressed and remitted SAD patients than in controls. No abnormalities of the circadian pacemaker were observed in SAD patients. A disturbance in thermoregulatory processes might explain the smaller circadian temperature amplitude in SAD patients during winter.