Bile acid metabolism and signaling.
Bile acid metabolism and signaling.
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DOI：
10.1002/cphy.c120023
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发表时间：
2013-07
影响因子：
5.8
通讯作者：
Chiang JY
中科院分区：
文献类型：
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作者：
Chiang JY
胆汁酸是肠道营养吸收和胆汁分泌脂质、毒性代谢物和外源性物质的重要生理因子。胆汁酸也是激活核受体和G蛋白偶联受体（GPCR）信号传导以调节肝脏脂质、葡萄糖和能量稳态并维持代谢稳态的信号传导分子和代谢调节剂。胆固醇转化为胆汁酸对于维持胆固醇稳态和防止胆固醇、甘油三酯和有毒代谢物的积累以及肝脏和其他器官的损伤至关重要。胆汁酸从肝脏到肠道再回到肝脏的肝肠循环在营养吸收和分布、代谢调节和体内平衡中起着核心作用。这一生理过程由肝和肠中的复杂膜转运系统调节，该系统由核受体调节。毒性胆汁酸可引起炎症、凋亡和细胞死亡。另一方面，胆汁酸激活的核和GPCR信号传导保护肝脏、肠和巨噬细胞免受炎症。胆汁酸代谢障碍导致胆汁淤积性肝病、血脂异常、脂肪肝疾病、心血管疾病和糖尿病。胆汁酸、胆汁酸衍生物和胆汁酸螯合剂是用于治疗人类慢性肝病、肥胖症和糖尿病的治疗剂。
Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and G protein-coupled receptor (GPCR) signaling to regulate hepatic lipid, glucose, and energy homeostasis and maintain metabolic homeostasis. Conversion of cholesterol to bile acids is critical for maintaining cholesterol homeostasis and preventing accumulation of cholesterol, triglycerides, and toxic metabolites, and injury in the liver and other organs. Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis. This physiological process is regulated by a complex membrane transport system in the liver and intestine regulated by nuclear receptors. Toxic bile acids may cause inflammation, apoptosis, and cell death. On the other hand, bile acid-activated nuclear and GPCR signaling protects against inflammation in liver, intestine, and macrophages. Disorders in bile acid metabolism cause cholestatic liver diseases, dyslipidemia, fatty liver diseases, cardiovascular diseases, and diabetes. Bile acids, bile acid derivatives, and bile acid sequestrants are therapeutic agents for treating chronic liver diseases, obesity, and diabetes in humans.
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影响因子：
2.9
作者：
Aldridge, MA;Ito, MK
通讯作者：
Ito, MK
DOI：
10.1073/pnas.0404297101
发表时间：
2004-08-03
影响因子：
11.1
作者：
Chen, GX;Liang, GS;Brown, MS
通讯作者：
Brown, MS
影响因子：
4.8
作者：
Bhatnagar, Sushant;Damron, Holly A.;Hillgartner, F. Bradley
通讯作者：
Hillgartner, F. Bradley
影响因子：
4.8
作者：
Baker, DM;Wang, SL;Davis, RA
通讯作者：
Davis, RA
DOI：
10.1038/nrm3312
发表时间：
2012-03-14
期刊：
Nature reviews. Molecular cell biology
影响因子：
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作者：
通讯作者：
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