Cerebral Hypoxia: Its Role in Age-Related Chronic and Acute Cognitive Dysfunction.
Cerebral Hypoxia: Its Role in Age-Related Chronic and Acute Cognitive Dysfunction.
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脑缺氧：其在年龄相关的慢性及急性认知功能障碍中的作用
DOI：
10.1213/ane.0000000000005525
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发表时间：
2021-06-01
影响因子：
5.7
通讯作者：
Floyd TF
中科院分区：
文献类型：
--
作者：
Snyder B;Simone SM;Giovannetti T;Floyd TF
据报道，术后认知功能障碍（POCD）的发生率差异很大，但似乎与衰老密切相关。在外科竞技场之外，由于呼吸、心血管或贫血状况，可能存在慢性和急性脑缺氧。缺氧已被广泛地牵涉到认知障碍，并且与缺氧相关的疾病状态伴随着衰老并随着衰老而进展。围手术期脑缺氧可能未被诊断，其对POCD的作用未被充分认识。在这里，我们讨论了各种疾病的过程和形式，其中缺氧可能有助于POCD。此外，我们概述了缺氧相关的机制，如缺氧诱导因子激活，脑缺血，脑血管储备，兴奋性毒性和神经炎症，这可能有助于认知障碍，以及这些机制如何与衰老相互作用。最后，我们讨论了预防和管理与缺氧相关的POCD的机会。
Postoperative Cognitive Dysfunction (POCD) has been reported with widely varying frequency but appears to be strongly associated with aging. Outside of the surgical arena, chronic and acute cerebral hypoxia may exist as a result of respiratory, cardiovascular, or anemic conditions. Hypoxia has been extensively implicated in cognitive impairment, and disease states associated with hypoxia accompany and progress with aging. Perioperative cerebral hypoxia is likely underdiagnosed and its contribution to POCD underappreciated. Herein we discuss the various disease processes and forms in which hypoxia may contribute to POCD. Further, we outline hypoxia-related mechanisms, such as hypoxia inducible factor activation, cerebral ischemia, cerebrovascular reserve, excitotoxicity, and neuroinflammation, which may contribute to cognitive impairment and how these mechanisms interact with aging. Finally, we discuss opportunities to prevent and manage POCD related to hypoxia.
影响因子：
3.7
作者：
Lourhmati A;Buniatian GH;Paul C;Verleysdonk S;Buecheler R;Buadze M;Proksch B;Schwab M;Gleiter CH;Danielyan L
通讯作者：
Danielyan L