Recent advances in obesity hypoventilation syndrome.
Recent advances in obesity hypoventilation syndrome.
复制标题
肥胖低通气综合征的最新进展。
作者：
B. Mokhlesi;A. Tulaimat
肥胖低通气综合征（OHS）由肥胖和慢性高碳酸血症合并伴有睡眠呼吸障碍组成。在过去的30年里，极度肥胖的流行在美国和其他国家显著增加。随着全球肥胖的流行，职业健康安全的患病率必然会增加。与睡眠呼吸紊乱的优生症患者相比，OHS患者的生活质量较低，医疗保健费用增加，患肺动脉高压和早期死亡的风险更高。尽管与该综合征相关的发病率和死亡率很高，但它往往未被认识到，治疗也经常被延误。临床医生必须保持高度的怀疑指数，因为早期识别和治疗可以减少与该综合征相关的发病率和死亡率的高负担。在这篇综述中，我们将讨论OHS的定义和临床表现，总结其流行情况，回顾目前对病理生理学的理解，并讨论治疗方案的最新进展。
Obesity hypoventilation syndrome (OHS) consists of a combination of obesity and chronic hypercapnia accompanied by sleep-disordered breathing. During the last 3 decades, the prevalence of extreme obesity has markedly increased in the United States and other countries. With a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life with increased health-care expenses and are at a higher risk for the development of pulmonary hypertension and early mortality compared to eucapnic patients with sleep-disordered breathing. Despite the significant morbidity and mortality associated with this syndrome, it is often unrecognized and treatment is frequently delayed. Clinicians must maintain a high index of suspicion since early recognition and treatment reduces the high burden of morbidity and mortality associated with this syndrome. In this review, we will discuss the definition and clinical presentation of OHS, provide a summary of its prevalence, review the current understanding of the pathophysiology, and discuss the recent advances in the therapeutic options.
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DOI：
10.5664/jcsm.26436
发表时间：
2006-01
期刊：
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
影响因子：
--
作者：
B. Mokhlesi;A. Tulaimat;A. T. Evans;Yue Wang;A. Itani;H. Hassaballa;J. Herdegen;E. Stepanski
通讯作者：
B. Mokhlesi;A. Tulaimat;A. T. Evans;Yue Wang;A. Itani;H. Hassaballa;J. Herdegen;E. Stepanski
DOI：
10.1164/rccm.200205-456pp
发表时间：
2003
影响因子：
24.7
作者：
Foster,GaryD
通讯作者：
Foster,GaryD
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
R. Norman;R. Goldring;Jeremy M. Clain;Beno W. Oppenheimer;A. Charney;D. Rapoport;K. Berger
通讯作者：
R. Norman;R. Goldring;Jeremy M. Clain;Beno W. Oppenheimer;A. Charney;D. Rapoport;K. Berger
DOI：
10.1164/ajrccm/147.4.887
发表时间：
1993-04-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
KRIBBS, NB;PACK, AI;DINGES, DF
通讯作者：
DINGES, DF
肥胖女性节食血清瘦素的短期和长期变化：热量限制和体重减轻的影响。
DOI：
10.1210/jcem.83.1.4494
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Wadden,TA;Considine,RV;Foster,GD;Anderson,DA;Sarwer,DB;Caro,JS
通讯作者：
Caro,JS