Diacyl disulfides as the precursors for hydrogen persulfide (H2S2).
Diacyl disulfides as the precursors for hydrogen persulfide (H2S2).
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DOI：
10.1016/j.bmcl.2019.126903
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发表时间：
2019-12
影响因子：
2.7
通讯作者：
Shi Xu;Yingying Wang;Zoel Parent;M. Xian
中科院分区：
文献类型：
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作者：
Shi Xu;Yingying Wang;Zoel Parent;M. Xian
虽然多硫化氢（H2Sn, n≥2）被认为在生物学中起着调节作用，但它们的基本化学和反应性仍然知之甚少。化合物可以产生H2Snare有用的工具。在这项工作中，我们发现在水溶液和有机溶剂中，由某些亲核试剂触发的二酰基二硫前体都可以有效地产生h2s2。利用该方法研究了H2S2的氧化还原反应，如清除1,1-二苯基-2-picrylhydrazyl自由基（DPPH）和还原tetrazines。
While hydrogen polysulfides (H2Sn, n ≥ 2) are believed to play regulatory roles in biology, their fundamental chemistry and reactivity are still poorly understood. Compounds that can produce H2Snare useful tools. In this work we found that H2S2could be effectively produced from diacyl disulfide precursors, triggered by certain nucleophiles, in both aqueous solutions and organic solvents. This method was used to explore redox reactions of H2S2, such as scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and reduction of tetrazines.