The cardiac valve interstitial cell
The cardiac valve interstitial cell
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DOI：
10.1016/s1357-2725(02)00100-0
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发表时间：
2003-02-01
影响因子：
4
通讯作者：
Yacoub, MH
中科院分区：
文献类型：
--
作者：
Taylor, PA;Batten, P;Yacoub, MH
心脏瓣膜间质细胞（IC）是一种异质且动态的特定细胞类型群体，具有许多独特的特征。它们负责维持细胞外支架，提供维持瓣膜独特动态行为所必需的机械特性。可以区分许多细胞表型：一些在整个瓣叶中稀疏排列，而另一些则排列成细束。这些细胞表达类似于骨骼肌、心脏和平滑肌细胞（SMC）的分子标志物，特别是，许多IC表达平滑肌（SM）α-肌动蛋白，肌成纤维细胞的标志物。在这方面，这些细胞表现出不同于皮肤成纤维细胞的特征，这可能暗示了它们在瓣膜功能中的作用。(C)2002爱思唯尔科技有限公司。保留所有权利。
Cardiac valve interstitial cells (ICs) are a heterogeneous and dynamic population of specific cell types that have many unique characteristics. They are responsible for maintaining the extracellular scaffold that provides the mechanical characteristics vital for sustaining the unique dynamic behaviour of the valve. A number of cellular phenotypes can be distinguished: some are sparsely arranged throughout the valve leaflets, whilst others are arranged in thin bundles. These cells express molecular markers similar to those of skeletal, cardiac and smooth muscle cells (SMCs) and in particular, many ICs express smooth muscle (SM) alpha-actin, a marker of myofibroblasts. In this respect, these cells exhibit a profile unlike skin fibroblasts, which may allude to their role in valve function. (C) 2002 Elsevier Science Ltd. All rights reserved.