Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins.
Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins.
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AIP、Calstabins 和 Presenilins 调节 Ryanodine 受体依赖性神经递质释放。
DOI：
10.1007/978-3-031-34229-5_11
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发表时间：
2023
影响因子：
--
通讯作者：
Riaz,Sadaf
中科院分区：
文献类型：
--
作者：
Wang,Zhao-Wen;Niu,Longgang;Riaz,Sadaf
Ryanodine受体（RyRs）是位于内质网膜上的Ca ~（2+）释放通道。突触前RyR在神经递质释放和突触可塑性中起重要作用。最近的研究表明，突触前RyR的正常功能依赖于几种调节蛋白，包括芳烃受体相互作用蛋白，钙蛋白和早老素。这些调节蛋白的功能障碍可以通过改变RyR的功能或表达来极大地影响神经递质释放和突触可塑性。本章旨在描述这些蛋白质和RyRs之间的相互作用，阐明它们在调节突触功能中的关键作用。
Ryanodine receptors (RyRs) are Ca2+release channels located in the endoplasmic reticulum membrane. Presynaptic RyRs play important roles in neurotransmitter release and synaptic plasticity. Recent studies suggest that the proper function of presynaptic RyRs relies on several regulatory proteins, including aryl hydrocarbon receptor-interacting protein, calstabins, and presenilins. Dysfunctions of these regulatory proteins can greatly impact neurotransmitter release and synaptic plasticity by altering the function or expression of RyRs. This chapter aims to describe the interaction between these proteins and RyRs, elucidating their crucial role in regulating synaptic function.