Cerebral correlates of delta waves during Non-REM sleep revisited
Cerebral correlates of delta waves during Non-REM sleep revisited
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DOI：
10.1016/j.neuroimage.2005.05.028
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发表时间：
2005-10-15
期刊：
影响因子：
5.7
通讯作者：
Peigneux, P
中科院分区：
文献类型：
--
作者：
Dang-Vu, TT;Desseilles, M;Peigneux, P
基于对正电子发射断层扫描(PET)睡眠数据集的统计分析，我们的目的是在非睡眠剥夺的正常年轻人中表征非快速眼动(NREM)睡眠期间Delta活动的神经关联。在NREM睡眠的第2-4阶段，在连续多导监测下使用H_2150进行115次正电子发射计算机断层扫描。用统计参数图(SPM2)分析局部脑血流量(RCBF)与Delta功率(1.5~4 Hz)频谱密度的相关性。NREM睡眠时头皮中央部位的Delta功率值与前额叶腹内侧皮质、基底前脑、纹状体、前脑岛和楔前叶的rCBF呈负相关。这些区域包含一组大脑区域，与快速眼动(REM)睡眠和清醒相比，慢波睡眠(SWS)期间rCBF下降(Maket，P.，Dgueldre，C.，Defflore，G.，Aerts，J.，Peter，J.M.，Luxen，A.，Franck，G.，1997)。人类慢波睡眠的功能神经解剖学。J.神经学17,2807-2812)，支持三角洲活动是NREM睡眠的一个有价值的显著特征的概念。在腹内侧额前区的rCBF与三角洲功率之间有很强的相关性，这与电生理研究相一致。与之前一项研究大脑活动与Delta相关的PET研究结果不同(Hofle，N.，Pans，T.，Ruten，D.，Fiset，P.，Gotman，J.，Evans，A.C.，Jones，II.E.，1997)。在人类的慢波睡眠中，局部脑血流量的变化是作为增量和纺锤波活动的函数。J.神经学17,4800-4808)，其中混合了清醒扫描和NREM睡眠扫描，没有发现与丘脑活动相关。后者的结果强调了在同步的NREM睡眠振荡中丘脑外的三角洲节律的重要性。因此，这种rCBF分布可能优先反映了在NREM睡眠期间参与皮质增量波产生的细胞过程的特定调制。(C)2005 Elsevier Inc.保留所有权利。
We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H2150 under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Defflore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Pans, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, II.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep. (c) 2005 Elsevier Inc. All rights reserved.