Preliminary observations of the effects on breast adenocarcinoma of plasma perfused over immobilized protein A.
Preliminary observations of the effects on breast adenocarcinoma of plasma perfused over immobilized protein A.
复制标题
固定化蛋白A灌注血浆对乳腺癌的影响的初步观察。
DOI：
10.1056/nejm198111123052006
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Daskal,Y
中科院分区：
文献类型：
--
作者：
Terman,DS;Young,JB;Shearer,WT;Ayus,C;Lehane,D;Mattioli,C;Espada,R;Howell,JF;Yamamoto,T;Zaleski,HI;Miller,L;Frommer,P;Feldman,L;Henry,JF;Tillquist,R;Cook,G;Daskal,Y
蛋白A是金黄色葡萄球菌1 （SpA）细胞壁的组成部分，与许多哺乳动物免疫球蛋白的Fc区发生反应，并与血清中的免疫复合物结合。1234以前，在一名结肠癌患者中观察到在固定SpA上循环自体血浆后的肿瘤杀灭作用。这种方法被扩展到患有自发性乳腺腺癌的狗身上，血浆灌注SpA后发现了快速而广泛的肿瘤坏死反应，而在缺乏蛋白a的葡萄球菌上则没有。这些发现已在一项独立研究中得到证实。类似的肿瘤坏死反应是…
PROTEIN A, a constituent of the cell wall ofStaphylococcus aureusCowans 1 (SpA), reacts with the Fc region of immunoglobulins from many mammalian species and combines with immune complexes in serum.1234Previously, tumoricidal effects were observed in a patient with cancer of the colon after administration of autologous plasma that had been circulated over immobilized SpA.5This approach was extended to dogs with spontaneous breast adenocarcinoma, and rapid and extensive tumor necrolytic reactions were noted after plasma perfusion over SpA but not over protein A-deficient staphylococcus.6,7These findings were confirmed in an independent study.8Similar tumor necrolytic responses were . . .