Evidence for two regions in the mouse t complex controlling transmission ratios.
Evidence for two regions in the mouse t complex controlling transmission ratios.
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小鼠 T 复合体中两个区域控制传动比的证据。
DOI：
10.1017/s0016672300020632
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
J. Klein
中科院分区：
文献类型：
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作者：
J. Styrna;J. Klein
四个新的t单倍型，t Tu 1至t Tu 4，被描述，其中三个来自t W12 TF单倍型和一个（t Tu 4）来自t W2单倍型。t Tu 1和t Tu 4单倍型导致T/t Tu 1或T/t Tu 4杂合子的无尾，缺乏致死因子，弱抑制T-H-2间隔的重组，并以接近孟德尔的比例从t Tu / +雄性传递给后代。t Tu 3单倍型类似于t Tu 1和t Tu 4，除了T/t Tu 3杂合子具有正常长度的尾巴。t Tu 2单倍型可能携带t Tu 12 tf的致死因子，抑制T-H-2和tf-H-2间隔中的交换，并显示稍微低于正常的传输比。在t Tu 1/t Tu 2复合杂合子中，t Tu 1染色体的雄性传递率与原始t Tu 12 tf单倍型的雄性传递率接近。在t Tu 3/t Tu 2杂合子中观察到类似的效果。这一观察结果被解释为两个地区内的t复杂的男性传动比控制的证据。其中一个区域靠近尾部修饰区，另一个区域靠近致死因子。我们的研究结果与果蝇分离扭曲系统中的结果非常相似。
Four new t haplotypes, t Tu1 through t Tu4 , are described, three of them derived from the t w12 tf haplotype and one ( t Tu4 ) from the t w2 haplotype. The t Tu1 and t Tu4 haplotypes cause taillessness in T/t Tu1 or T/t Tu4 heterozygotes, lack the lethality factor, weakly suppress recombination in the T−H−2 interval, and are transmitted to offspring from t Tu / + males at nearly Mendelian ratios. The t Tu3 haplotype resembles t Tu1 and t Tu4 except for the fact that the T/t Tu3 heterozygotes have normal-length tails. The t Tu2 haplotype probably carries the lethal factor of t Tu12 tf , suppresses crossing-over in the T-H-2 and tf-H-2 intervals, and displays a slightly subnormal transmission ratio. In the compound heterozygote t Tu1 /t Tu2 , the male transmission ratio of the t Tu1 chromosome is close to that of the original t Tu12 tf haplotype. A similar effect is observed in the t Tu3 /t Tu2 heterozygote. This observation is interpreted as evidence for two regions within the t complex controlling the male transmission ratios. One of the regions is close to the tail-modifying region, the other is close to the lethality factor. Our findings parallel closely those made in the segregation distorter system in Drosophila .