The Potential of Probiotics as a Therapy for Osteoporosis.
The Potential of Probiotics as a Therapy for Osteoporosis.
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DOI：
10.1128/microbiolspec.bad-0015-2016
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发表时间：
2017-08
影响因子：
3.7
通讯作者：
McCabe LR
中科院分区：
文献类型：
--
作者：
Collins FL;Rios-Arce ND;Schepper JD;Parameswaran N;McCabe LR
骨质疏松症以骨量减少和骨组织微结构恶化为特征，骨折风险增加，可分为两种形式：原发性或继发性，取决于它是作为自然衰老过程的一部分(雌激素缺乏)还是作为疾病病理的一部分发生的。在这两种情况下，骨丢失都是由于骨重建过程中的不平衡，吸收/形成更偏向于骨丢失。最近的研究和新出现的证据不断证明肠道微生物区系调节骨骼健康的潜力。本章讨论了骨重建的过程和骨质疏松的病理，并介绍了肠道微生物区系及其对骨健康的潜在影响。特别是，我们重点介绍了最近的小鼠研究，这些研究考察了益生菌补充剂如何既可以增加健康个体的骨密度，又可以预防原发性(雌激素缺乏)以及继发性骨质疏松症。描述了解释益生菌治疗如何对骨骼健康发挥有益作用的潜在机制。
Osteoporosis, characterized by low bone mass and micro-architectural deterioration of bone tissue with increased risk of fracture, can be categorized into two forms: primary or secondary, depending on whether it occurs as part of the natural aging process (estrogen-deficiency) or as part of disease pathology. In both forms bone loss is due to an imbalance in the bone remodeling process with resorption/formation skewed more toward bone loss. Recent studies and emerging evidence consistently demonstrate the potential of the intestinal microbiota to modulate bone health. The current chapter discusses the process of bone remodeling and the pathology of osteoporosis and introduces the intestinal microbiota and its potential to influence bone health. In particular, we highlight recent murine studies that examine how probiotic supplementation can both increase bone density in healthy individuals as well as protect against primary (estrogen-deficiency) as well as secondary osteoporosis. Potential mechanisms are described to account for how probiotic treatments could be exerting their beneficial effect on bone health.