SPATIAL SUMMATION OF CHEMICAL IRRITATION AND ITCH PRODUCED BY TOPICAL APPLICATION OF CAPSAICIN
SPATIAL SUMMATION OF CHEMICAL IRRITATION AND ITCH PRODUCED BY TOPICAL APPLICATION OF CAPSAICIN
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DOI：
10.3758/bf03205007
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发表时间：
1990-07-01
期刊：
影响因子：
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通讯作者：
GREEN, BG
中科院分区：
文献类型：
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作者：
GREEN, BG
在两个实验中研究了增加刺激的总面积对局部应用辣椒素产生的刺激感觉的影响。在第一个实验中，通过改变将辣椒素递送到前臂皮肤上的滤纸盘的大小来改变刺激区域。受试者在15分钟内对皮肤感觉的强度和质量进行评分。刺激面积增加15倍导致刺激的峰值感知强度相对适度增加，刺激发作的潜伏期缩短，以及瘙痒和刺痛/刺痛感觉报告频率的变化。然而，无论刺激大小如何，瘙痒是最常报告的感觉。在实验2中，通过改变施加到皮肤的刺激的数量来操纵刺激区域。尽管总刺激面积的差异较小（9倍对15倍），但感知刺激的差异比实验1中更明显，并达到统计学显著性。因此，可以得出结论，空间求和确实发生在负责皮肤上辣椒素的感知的传入系统或系统中。这一结果是一致的，与以前的报告的总和在阈值的热痛，并构成了新的信息的空间整合的刺激。
The effect of increasing the total area of stimulation on the sensations of irritation produced by topical application of capsaicin was studied in two experiments. In the first experiment, stimulus area were varied by changing the size of the filter paper disks on which capsaicin was delivered to the skin of the forearm. Subjects rated the intensity and quality of the cutaneous sensations over a 15-min period. Increasing stimulus area by a factor of 15 resulted in a relatively modest increase in the peak perceived intensity of irritation, a shortening of the latency to the onset of irritation, and shifts in the frequency of reports of sensations of itching and stinging/pricking. However, itch was the most frequently reported sensation regardless of stimulus size. In Experiment 2, stimulus area was manipulated by varying the number of stimuli applied to the skin. Despite a smaller difference in total stimulus areas (9-fold vs. 15-fold), the difference in perceived irritation was more pronounced than it was in Experiment 1 and reached statistical significance. It is therefore concluded that spatial summation does occur in the afferent system or systems responsible for the perception of capsaicin on the skin. This result is consistent with previous reports of summation at the threshold for heat pain and constitutes new information about the spatial integration of pruritic stimulation.