Sex differences in brain aging - A quantitative magnetic resonance imaging study
Sex differences in brain aging - A quantitative magnetic resonance imaging study
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DOI：
10.1001/archneur.55.2.169
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发表时间：
1998-02-01
影响因子：
--
通讯作者：
Bryan, RN
中科院分区：
文献类型：
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作者：
Coffey, CE;Lucke, JF;Bryan, RN
背景资料：鲜为人知的是，性别对年龄相关的变化在brainstructure.Methods：定量磁共振成像的大脑进行了330名老年人（年龄范围，66-96岁）志愿者独立生活在社区，所有这些人都参与了心血管健康研究。通过计算机辅助边缘检测和跟踪方法，从T-1加权轴向图像中盲法测量整体和局部脑大小。高测量reliabilities是gathered.Results：脑大小的特定变化在男性比女性的外周（沟）脑脊液量，侧裂（sylvian）脑脊液量，顶枕区面积显着更大。年龄的主要影响，观察所有其余的大脑区域（大脑半球体积，额区面积，颞顶区面积，侧脑室体积，第三脑室体积），但这些影响是相似的男性和女性。大脑结构的不对称性不受任何性别衰老的影响。结论：我们的结果与少数已发表的关于大脑衰老性别差异的研究基本一致，并表明，至少对于某些结构，男性的衰老影响可能比女性更明显。这些性别差异的神经生物学基础和功能相关性需要进一步研究。
Background: Little is known about the effect of sex on age-related changes in brain structure.Methods: Quantitative magnetic resonance imaging of the brain was performed in 330 elderly (age range, 66-96 years) volunteers living independently in the community, all of whom were participants in the Cardiovascular Health Study. Blinded measurements of global and regional brain size were made from T-1-weighted axial images by means of computer-assisted edge detection and trace methods. High measurement reliabilities were obtained.Results: Age-specific changes in brain size were significantly greater in men than women for the peripheral (sulcal) cerebrospinal fluid volume, the lateral (sylvian) fissure cerebrospinal fluid volume, and the parietooccipital region area. Main effects of age were observed for all the remaining brain regions examined (cerebral hemisphere volume, frontal region area, temporoparietal region area, lateral ventricular volume, and third ventricle volume), but these effects were similar in men and women. Asymmetries in brain structures were not affected by aging in either sex.Conclusions: Our results are generally consistent with the few published studies on sex differences in brain aging and suggest that, for at least some structures, aging effects may be more apparent in men than women. The neurobiological bases and functional correlates of these sex differences require further investigation.