Syntheses of Arylacetone and Arylacetonitrile by Friedel-Crafts Reaction with α-Chloro-α-(methylthio)-substituted Acetone and Acetonitrile
Syntheses of Arylacetone and Arylacetonitrile by Friedel-Crafts Reaction with α-Chloro-α-(methylthio)-substituted Acetone and Acetonitrile
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α-氯-α-(甲硫基)取代丙酮和乙腈的傅克反应合成芳基丙酮和芳基乙腈
DOI：
10.1248/cpb.30.3574
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发表时间：
1982
影响因子：
1.7
通讯作者：
H. Ishibashi*
中科院分区：
文献类型：
--
作者：
Y. Tamura;H. Choi;M. Mizutani;Y. Ueda;H. Ishibashi*
介绍了芳基丙酮和芳基乙腈的新制备方法。在刘易斯酸存在下，芳香族化合物分别与α-氯-α-甲硫基丙酮（4）和α-氯-α-甲硫基乙腈（7）发生Friedel-Crafts反应，得到α-甲硫基芳基丙酮（5）和α-甲硫基芳基乙腈（8）。化合物（5）和（8）在乙酸中用锌粉还原，分别得到相应的芳基丙酮（6）和芳基乙腈（9）。
Novel preparative methods for arylacetone and arylacetonitrile are described. Friedel-Crafts reactions of aromatic compounds with α-chloro-α-(methylthio) acetone (4) and α-chloro-α-(methylthio) acetonitrile (7) in the presence of Lewis acid afforded α-(methylthio)-arylacetone (5) and α-(methylthio) arylacetonitrile (8), respectively. Compounds (5) and (8) were converted into the corresponding arylacetone (6) and arylacetonitrile (9) by reduction with zinc dust in acetic acid.