Purified mucins in drug delivery research.
Purified mucins in drug delivery research.
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DOI：
10.1016/j.addr.2021.113845
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发表时间：
2021-06
影响因子：
16.1
通讯作者：
M. Marczynski;Ceren Kımna;O. Lieleg
中科院分区：
文献类型：
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作者：
M. Marczynski;Ceren Kımna;O. Lieleg
药物输送领域的主要挑战之一仍然是开发有效运输药物穿过粘液屏障的策略，粘液屏障调节分子和颗粒在身体所有管腔空间中的通过和保留。彻底了解控制这种选择性渗透性的分子机制是实现药物和药物载体有效易位的关键。为此，基于纯化粘蛋白的模型系统可以提供有价值的信息。在这篇综述中，我们总结了此类基于粘蛋白的模型系统在药物递送研究领域取得的进展：首先，我们概述了粘蛋白纯化程序，并讨论了从纯化粘蛋白重构的模型系统模拟天然粘液的适用性。然后，我们总结了研究粘蛋白结合的技术。最后，我们重点介绍利用粘蛋白作为药物输送平台的构建模块或使用粘蛋白作为活性化合物的方法。
One of the main challenges in the field of drug delivery remains the development of strategies to efficiently transport pharmaceuticals across mucus barriers, which regulate the passage and retention of molecules and particles in all luminal spaces of the body. A thorough understanding of the molecular mechanisms, which govern such selective permeability, is key for achieving efficient translocation of drugs and drug carriers. For this purpose, model systems based on purified mucins can contribute valuable information. In this review, we summarize advances that were made in the field of drug delivery research with such mucin-based model systems: First, we give an overview of mucin purification procedures and discuss the suitability of model systems reconstituted from purified mucins to mimic native mucus. Then, we summarize techniques to study mucin binding. Finally, we highlight approaches that made use of mucins as building blocks for drug delivery platforms or employ mucins as active compounds.