Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice
Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice
复制标题
食物限制会降低小鼠的皮质骨量和血清胰岛素样生长因子-1 水平并促进子宫萎缩
DOI：
10.1016/j.bbrc.2020.11.122
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Miyamoto T
中科院分区：
文献类型：
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作者：
Ito E;Sato Y;Kobayashi T;Nakamura S;Kaneko Y;Soma T;Matsumoto T;Kimura A;Miyamoto K;Matsumoto H;Matsumoto M;Nakamura M;Sato K;Miyamoto T
女性运动员能量消耗低通常会导致下丘脑闭经和骨质疏松症，进而促进应力性骨折。这些病症背后的机制仍不清楚。在这里，我们发现，与对照小鼠相比，接受食物限制（FR）或FR加自愿跑步运动的模型小鼠的骨矿物质密度、皮质骨参数和子宫重量显着降低，并且这些参数在FR加运动组中恶化。与对照组相比，FR 和 FR 加运动组的矿物质沉积率和破骨细胞数量显着降低，血清胰岛素样生长因子 1 (IGF1) 水平显着降低。 ED71 或 1.25(OH)2D3 治疗挽救了结果。因此，我们得出结论，服用活性维生素 D 类似物是预防这些病症的一种可能的治疗方法。
Low energy availability in female athletes often causes hypothalamic amenorrhea and osteoporosis, in turn promoting stress fractures. Mechanisms underlying these conditions remain unclear. Here we show that model mice subjected to food restriction (FR) or FR-plus-voluntary running exercise exhibit significantly reduced bone mineral density, cortical bone parameters and uterine weight than do control mice, and that these parameters worsen in the FR-plus-exercise group. Relative to controls, FR and FR-plus-exercise groups showed significantly lower mineral apposition rate and osteoclast number and significantly reduced serum insulin-like growth factor-1 (IGF1) levels. Outcomes were rescued by ED71 or 1.25(OH)2D3treatment. Thus, we conclude that administration of active vitamin D analogues represents a possible treatment to prevent these conditions.