Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast.
Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast.
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Accreta使完整的胎盘普遍存在复杂化的特征是血管内皮生长因子的全身水平降低以及侵入性滋养细胞的上皮到间质转变。
DOI：
10.1016/j.ajog.2010.12.027
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发表时间：
2011-05
影响因子：
9.8
通讯作者：
Buhimschi CS
中科院分区：
文献类型：
--
作者：
Wehrum MJ;Buhimschi IA;Salafia C;Thung S;Bahtiyar MO;Werner EF;Campbell KH;Laky C;Sfakianaki AK;Zhao G;Funai EF;Buhimschi CS
描述完全性前置胎盘患者血清血管生成因子的特征，并确定侵袭性滋养细胞分化的特征性植入、植入或植入是否具有上皮间质转化（EMT）的特征。我们分析了90例完全性前置胎盘（n=45）或无并发症妊娠（n =45）孕妇的胎龄匹配血清样本。免疫组化检测血管内皮生长因子（VEGF）、胎盘生长因子（PlGF）和可溶性fms样酪氨酸激酶-1（sFlt-1）。VEGF和磷酸酪氨酸（P-Tyr）的免疫反应性进行了调查，在组织学标本相对于波形蛋白和细胞角蛋白-7的表达。患有前置胎盘和侵袭性胎盘形成的女性[accreta（n=5）; increta（n=6）; percreta（n=2）]的全身VEGF较低（侵袭性前置胎盘：中位数[IQR]：0.8[0.02-3.4] vs.对照组：6.5[2.7-10.5] pg/mL，P=0.02）。VEGF和P-Tyr免疫染色在浸润性绒毛外滋养细胞（EVT）中占主导地位，共表达波形蛋白和细胞角蛋白-7，EMT特征和肿瘤样细胞表型。较低的全身游离VEGF和间质性EVT向亚稳态细胞表型的转变是前置胎盘过度肌层浸润的特征。
To characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta or percreta shares features of epitehelial-mesenchymal-transition (EMT). We analyzed gestational age matched serum samples from 90 pregnant women with either complete placenta previa (n=45) or uncomplicated pregnancies (n=45). Vascular-endothelial-growth-factor (VEGF), placental-growth-factor (PlGF) and soluble fms-like-tyrosine-kinase-1 (sFlt-1) were immunoassayed. VEGF and phosphotyrosine (P-Tyr) immunoreactivity was surveyed in histological specimens relative to expression of vimentin and cytokeratin-7. Women with previa and invasive placentation [accreta (n=5); increta (n=6); percreta (n=2)] had lower systemic VEGF (invasive previa: median [IQR]: 0.8[0.02–3.4] vs. control: 6.5[2.7–10.5] pg/mL, P=0.02). VEGF and P-Tyr immunostaining predominated in the invasive extravillous trophoblasts (EVT) which co-expressed vimentin and cytokeratin-7, a EMT feature and tumor-like cell phenotype. Lower systemic free VEGF and a switch of the interstitial EVT to a metastable cell phenotype characterize placenta previa with excessive myometrial invasion.
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影响因子：
2.4
作者：
Charnock-Jones, DS
通讯作者：
Charnock-Jones, DS
DOI：
10.1016/s0002-9378(15)33242-7
发表时间：
1980-01-01
影响因子：
9.8
作者：
COTTON, DB;READ, JA;QUILLIGAN, EJ
通讯作者：
QUILLIGAN, EJ
影响因子：
3.8
作者：
KHONG, TY;ROBERTSON, WB
通讯作者：
ROBERTSON, WB
影响因子：
7.2
作者：
Buhimschi, Catalin S.;Magloire, Lissa;Buhimschi, Irina A.
通讯作者：
Buhimschi, Irina A.
影响因子：
7.1
作者：
Chou, MM;Ho, ESC;Lee, YH
通讯作者：
Lee, YH