ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators.
ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators.
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DOI：
10.1021/acsmacrolett.5b00565
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发表时间：
2015-09-15
影响因子：
7.015
通讯作者：
Pun SH
中科院分区：
文献类型：
--
作者：
Wei H;Wang CE;Tan N;Boydston AJ;Pun SH
具有先进结构的聚合物现在可以很容易地和可重复地合成使用受控活性聚合。这些材料由于其可调节的尺寸、药物掺入和释放的通用方法以及易于与靶向配体功能化而成为潜在的药物载体。在这项工作中，我们报告了大环刷状或“向日葵”聚合物的设计和开发，该聚合物由环状多引发剂“核心”通过控制自由基聚合合成亲水性“花瓣”。这些纳米结构可以合成具有低多分散性和根据聚合时间控制尺寸的纳米结构。我们进一步证明叶酸功能化向日葵聚合物促进受体介导的摄取进入癌细胞。因此，这些材料显示出作为抗癌治疗药物载体的潜力。
Polymers with advanced architectures can now be readily and reproducibly synthesized using controlled living polymerization. These materials are attractive as potential drug carriers due to their tunable size, versatile methods of drug incorporation and release, and ease of functionalization with targeting ligands. In this work, we report the design and development of macrocyclic brush, or “sunflower,” polymers, synthesized by controlled radical polymerization of hydrophilic “petals” from a cyclic multimacroinitiator “core.” These nanostructures can be synthesized with low polydispersity and controlled sizes depending on polymerization time. We further demonstrate that folate-functionalized sunflower polymers facilitate receptor-mediated uptake into cancer cells. These materials therefore show potential as drug carriers for anti-cancer therapies.