Cortical expression of prolactin (PRL), growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is not increased in experimental traumatic brain injury.
Cortical expression of prolactin (PRL), growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is not increased in experimental traumatic brain injury.
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在实验性脑外伤中，催乳素（PRL）、生长激素（GH）和促肾上腺皮质激素（ACTH）的皮质表达没有增加。
DOI：
10.1007/978-3-211-85578-2_75
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Robertson,CS
中科院分区：
文献类型：
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作者：
Goodman,JC;Cherian,L;Robertson,CS
研究背景脑缺血损伤时垂体激素催乳素（PRL）和生长激素（GH）的表达有报道。这两种激素都可能参与血管张力调节和血管生成，生长激素被认为是神经保护性的，而催乳素刺激星形胶质细胞增生。方法我们使用组织芯片技术在创伤性脑损伤（TBI）的受控皮质撞击模型中检测催乳素、生长激素和促肾上腺皮质激素（ACTH）的表达。创伤性脑损伤不会导致大脑皮质中垂体激素PRL和GH的上调。
BackgroundCerebral cortical expression of the pituitary hormones prolactin (PRL) and growth hormone (GH) have reported in ischemic damage. Both hormones may be involved in vascular tone regulation and angiogenesis, and growth hormone is thought to be neuroprotective while prolactin stimulates astrogliosis.MethodsWe examined expression of prolactin, growth hormone and adrenocorticotrophic hormone (ACTH) using tissue microarray technology in the controlled cortical impact model of traumatic brain injury (TBI).FindingsNo increased expression of these hormones was seen.ConclusionsUnlike ischemia, traumatic brain injury does not result in up-regulation of the pituitary hormones PRL and GH in cerebral cortex.