Eosinophilic gastroenteritis:: A review
Eosinophilic gastroenteritis:: A review
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DOI：
10.1007/s10620-005-9011-2
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发表时间：
2007-11-01
影响因子：
3.1
通讯作者：
Uribe, Misael
中科院分区：
文献类型：
--
作者：
Mendez-Sanchez, Nahum;Chavez-Tapia, Norberto C.;Uribe, Misael
嗜酸性胃肠炎是一种罕见的良性疾病，其特征是组织嗜酸性浸润，可累及消化道数层。也被称为过敏性或嗜酸性粒细胞过敏性胃肠炎，它通常涉及胃和小肠：很少涉及结肠。它可能或可能不伴有外周血中嗜酸性粒细胞计数增高。主要临床表现取决于受累部位。它根据临床和病理特征进行分类，症状取决于患者对嗜酸性粒细胞释放的几种细胞因子的免疫反应。由于缺乏对病因和触发因素的了解，治疗主要基于皮质类固醇；尽管已经测试了其他作用于免疫系统的药物，但结果并不总是令人满意。本文综述了该病的流行病学、病理生理学、临床特点和治疗方法。
Eosinophilic gastroenteritis is a rare benign disease characterized by tissue eosinophilic infiltration that may involve several digestive tract layers. Also known as allergic, or eosinophilic allergic, gastroenteropathy, it usually involves the stomach and small intestine: rarely the colon. It may or may not be accompanied by higher counts of eosinophils in the peripheral blood. The main clinical manifestations depend on the site affected. It has been classified according to clinical and pathological features, and the symptoms depend on the patient's immunological response to several cytokines released by eosinophils. Because of lack of understanding of the etiology and triggering factors, treatment is based mainly on corticosteroids; although other drugs acting on the immune system have been tested, the results are not always satisfactory. This review focuses on the epidemiology, pathophysiology, clinical features, and treatment of this hitherto under-diagnosed disease.