Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience .15.
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience .15.
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DOI：
10.1212/wnl.46.6.1592
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发表时间：
1996-06-01
期刊：
影响因子：
9.9
通讯作者：
Heyman, A
中科院分区：
文献类型：
--
作者：
Ellis, RJ;Olichney, JM;Heyman, A
我们研究了117例尸检证实为AD的CERAD受试者中脑淀粉样血管病（CAA）的频率、严重程度和临床相关性。83%的人表现出至少轻度的淀粉样血管病。117例脑中有30例（25.6%）显示中度至重度CAA影响一个或多个皮质区域的脑血管。这些大脑也显示出比那些很少或没有淀粉样血管病的受试者更高的血管病变或缺血性病变的频率（43.3%对23.0%;比值比= 2.6，95% CI = 1.1至6.2）。高CAA评分也与脑卒中的存在和老年痴呆症的发病年龄相关。我们的研究结果表明，导致非AD相关血管病变的因素（例如，动脉粥样硬化）可能在AD脑血管中淀粉样蛋白沉积中起作用。
We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral asteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.