Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres
Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres
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DOI：
10.1093/cercor/9.6.543
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发表时间：
1999-09-01
期刊：
影响因子：
3.7
通讯作者：
Lai, ES
中科院分区：
文献类型：
--
作者：
Dou, CL;Li, S;Lai, ES
脑因子-1（BF-1）是一种翼螺旋（WH）转录因子，在神经管中具有有限的表达模式。在胚胎中，BF-1定位于最吻端神经管（端脑神经上皮）的祖细胞。BF-1的表达持续存在于成人脑中的端脑衍生结构中，包括大脑皮质、海马、嗅球和基底神经节。在小鼠中靶向破坏BF-1基因导致大脑半球发育不全。端脑神经上皮细胞的增殖减少，神经元分化过早发生。BF-1（-/-）突变体的前脑也显示背腹侧图案缺陷。端脑腹侧（基底）区域的发育比背侧区域受到更严重的影响。这些异常与端脑背侧神经上皮中BMP 4的异位表达和端脑腹侧中shh的缺失有关。这些结果提高了BF-1可能通过调节作用于端脑神经上皮的诱导信号的表达或活性来调节祖细胞增殖和区域图案化的可能性。
Brain factor-1 (BF-1) is a winged-helix (WH) transcription factor with a restricted pattern of expression in the neural tube. In the embryo, BF-1 is localized to the progenitor cells of the most rostral neural tube, the telencephalic neuroepithelium. Expression of BF-1 persists in the adult brain in the structures derived from the telencephalon, including the cerebral cortex, the hippocampus, the olfactory bulbs and the basal ganglia. Targeted disruption of the BF-1 gene in mice results in hypoplasia of the cerebral hemispheres. Proliferation of the telencephalic neuroepithelium is decreased and neuronal differentiation occurs prematurely The forebrain of the BF-1 (-/-) mutant also displays dorsal-ventral patterning defects. Development of the ventral (basal) region of the telencephalon is more severely affected than the dorsal region. These anomalies are associated with the ectopic expression of BMP4 in the dorsal telencephalic neuroepithelium and the loss of shh in the ventral telencephalon. These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium.