Chemotherapy and tumor microenvironment of pancreatic cancer.
Chemotherapy and tumor microenvironment of pancreatic cancer.
复制标题
胰腺癌的化疗与肿瘤微环境
DOI：
10.1186/s12935-017-0437-3
复制
发表时间：
2017
影响因子：
5.8
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Liu Q;Liao Q;Zhao Y
胰腺癌是一种极其凶险的恶性肿瘤。化疗已被广泛用于治疗这种棘手的肿瘤。胰腺癌拥有独特的肿瘤微环境（TME），其特征为致密的结缔组织增生以及免疫抑制细胞的大量浸润。基质细胞与癌细胞之间的相互作用在影响胰腺癌生物学行为方面起着至关重要的作用。针对胰腺癌基质成分的治疗已显示出有前景的结果。除了化疗药物对癌细胞的直接毒性作用外，它们还可以重塑肿瘤微环境，最终影响其疗效。在此，我们综述了以下四个方面：（1）自2000年以来胰腺癌化疗的临床标志性进展；（2）基质细胞与胰腺癌细胞之间的相互作用及机制；（3）化疗对肿瘤微环境的重塑作用及机制；（4）针对胰腺癌基质成分的治疗。
本文的网络版本（doi:10.1186/s12935 - 017 - 0437 - 3）包含补充材料，仅授权用户可获取。
Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and profound infiltrations of immunosuppressive cells. Interactions between stromal cells and cancer cells play vital roles to affect the biological behaviors of pancreatic cancer. Targeting the stromal components of pancreatic cancer has shown promising results. In addition to the direct toxic effects of chemotherapeutic drugs on cancer cells, they can also remodel the TME, eventually affecting their efficacy. Herein, we reviewed the following four aspects; (1) clinical landmark advances of chemotherapy in pancreatic cancer, since 2000; (2) interactions and mechanisms between stromal cells and pancreatic cancer cells; (3) remodeling effects and mechanisms of chemotherapy on TME; (4) targeting stromal components in pancreatic cancer.